Digital Bullet Agency is making big moves in the U.S., growing its reach in the AI-driven marketing world. This agency stands out for how it uses AI to boost search engine optimization (SEO), helping real estate investors and agencies strengthen their hold locally. The goal of this expansion is to make their expertise available to more businesses, using advanced AI tools and strategies to amp up digital visibility.
This move follows Digital Bullet’s latest acquisition of REIPilot.ai. This exciting addition is set to boost the agency’s operations, promising better efficiency and more value for their clients. By weaving in cutting-edge technology, Digital Bullet Agency aims to cement its role as a frontrunner in the industry, enhancing their ability to provide full-service SEO solutions that pack a punch.
Keith Dean, a familiar face in the digital marketing scene and a key representative at Digital Bullet Agency, shared his thoughts on this growth. “Our expansion into the U.S. market is a testament to our commitment to delivering top-tier AI-enhanced SEO services,” Dean noted. “We’re always on the hunt to grow our capabilities, and acquiring REIPilot.ai marks an exciting step for us.”
Over the last decade, Digital Bullet Agency has earned a strong reputation for offering effective, data-driven SEO strategies. By tapping into AI technology, the agency crafts tailored marketing approaches that meet each client’s unique needs. Their services include developing comprehensive SEO strategies, creating content that appeals to both search engines and people, and offering specialized video SEO services. These services give businesses practical insights to boost their rankings, increase traffic, and drive conversions.
Digital Bullet Agency is transforming the usual SEO techniques by integrating AI in smart ways. By doing so, they not only enhance human expertise but also encourage strategic and creative thinking amongst their team. This mix of human and AI input leads to a more effective marketing process, bringing continuous improvements from AI insights.
With the tools and processes at their website, businesses can tap into the potential of digital marketing to better engage with their audiences. In today’s business world, having a strong digital presence is crucial, especially as more interactions and engagements go online. Digital Bullet Agency offers three distinct monthly packages—Starter, Most Popular, and Enterprise—to suit businesses of different sizes and goals.
Their presence on LinkedIn further underscores Digital Bullet Agency’s role as a leader in digital marketing. Visit their LinkedIn page at https://uk.linkedin.com/in/digitalbulletagency for more details about the agency’s significant accomplishments and its team’s dedication to service excellence.
Keith Dean shared more about the agency’s mission. “Our mission is to empower businesses with the capabilities they need to thrive in a competitive digital environment,” Dean explained. “Expanding our reach isn’t just about covering more ground; it’s about exploring new tech and partnerships that can offer incredible benefits.”
Looking ahead, Digital Bullet Agency is set on being a game-changer in digital marketing. Their current path positions them to bring advanced SEO solutions and AI applications to businesses wanting to make a big impact online. The U.S. expansion, combined with the REIPilot.ai acquisition, is a major step forward in the agency’s mission to deliver top-notch results and help clients succeed globally. Explore how their innovative AI-driven SEO services can make a difference in any business at https://digitalbulletagency.com/.
Gullco International, a leading manufacturer of welding automation equipment, announces the continued success of mechanized welding solutions in transforming fabrication operations across multiple industries. With over seventy years of specialized expertise in welding technology, the company has established itself as a trusted provider of automated welding carriages, tractors, and custom systems that enable fabricators to achieve superior weld quality while significantly reducing production timeframes compared to traditional manual welding processes.
In many fabrication environments, manual welding inconsistencies can severely limit throughput and profitability. The prevalence of defects like undercut, poor fusion, and porosity often necessitate costly rework, consuming labor hours that could be billed elsewhere. Gullco International understands that every minute spent grinding or repairing welds not only causes delays but also wastes expensive consumables, directly impacting a company’s bottom line. Mechanized welding solutions, with their precise control over torch angle and travel speed, address these issues head-on by significantly reducing the need for repairs, helping fabricators keep projects on schedule and under budget.
Project deadlines are frequently compromised due to the limitations of manual welding, making arc-on time a critical bottleneck. When welders must frequently pause to reposition the torch or recover from fatigue, productivity stalls. Gullco’s mechanized carriages and tractors maintain a consistent welding speed along seams, particularly beneficial on long or complex welds. This steady performance increases arc-on time, enabling fabricators to meet tight deadlines and secure contracts that require reliable and timely completions. By improving operational efficiency, mechanized welding eliminates the domino effect that delays can cause throughout the production chain.
Operator safety remains a paramount concern in welding shops worldwide. The demanding conditions of manual welding—exposure to intense heat, hazardous fumes, and prolonged awkward postures—contribute to both long-term health risks and day-to-day operator fatigue. Gullco International’s mechanized welding solutions protect operators by distancing them from direct arc exposure and reducing ergonomic strain, ensuring both safety and sustained weld quality. This dual benefit fosters a healthier workforce and diminishes accident risks, directly translating to improved morale and lower downtime.
One cornerstone of Gullco’s offering is the KAT® Automation Carriage, a rugged and versatile device capable of handling all-position welding. Whether working vertically, horizontally, or overhead, this carriage maintains flawless torch positioning and speed, thereby removing operator strain and delivering repeatable welds on the most challenging joints. Whether fabricating structural steel components or erecting a tank or ship hull, the KAT® serves as a reliable partner to skilled welders, allowing them to focus on crucial adjustments rather than manual control.
Adopting mechanized welding solutions is not merely an upgrade in equipment; it’s an investment in operational excellence that pays dividends through reduced rework, higher throughput, and improved weld quality and safety. Gullco International provides a seamless process for fabricators to integrate mechanization into their workflows, starting with a consultation to understand specific requirements. The company’s application experts then recommend the precise equipment package that delivers the fastest return on investment and the greatest competitive advantage.
Jeff Zook, Director at Gullco International, emphasizes the company’s dedication to helping fabricators thrive in a challenging market. “Our mission has always been to empower welding professionals by providing mechanized tools that complement their craftsmanship. We know that precision, efficiency, and safety are non-negotiable and strive to deliver equipment that supports these values, enabling shops to produce perfect welds reliably and on schedule,” Zook stated.
As industries evolve and fabrication demands grow increasingly complex, mechanized welding solutions by Gullco International represent a proven path forward. These systems bridge the gap between manual welding’s flexibility and full automation’s rigidity, offering fabricators a balance of control and consistency. The result is a more efficient, profitable, and safer workplace that can confidently meet today’s production challenges and win tomorrow’s jobs.
Fabricators continuing with manual welding alone risk falling behind competitors, suffering from chronic rework, delays, and lost contracts. Embracing Gullco’s mechanized welding technology is a strategic choice that protects profitability, reputation, and workforce wellbeing. By leveraging equipment trusted on the world’s most demanding jobsites, fabricators gain an undeniable advantage in quality, speed, and safety that helps secure long-term success in a competitive landscape.
Gullco International remains committed to partnering with fabricators worldwide, delivering expert support and industry-renowned mechanized welding solutions that unlock new levels of productivity and quality. Through dedication to innovation and customer success, Gullco’s solutions continue to set the standard for mechanized welding excellence that fabricators can depend on every day.
MCLEAN, VA / ACCESS Newswire / August 12, 2025 / Gladstone Investment Corporation (Nasdaq:GAIN) (the “Company”) today announced earnings for its first fiscal quarter ended June 30, 2025. Please read the Company’s Quarterly Report on Form 10-Q, filed today with the U.S. Securities and Exchange Commission (the “SEC”), which is available on the SEC’s website at www.sec.gov or the investors section of the Company’s website at www.gladstoneinvestment.com.
Summary Information: (dollars in thousands, except per share data (unaudited)):
June 30, 2025
March 31, 2025
$
Change
%
Change
For the quarter ended:
Total investment income
$
23,544
$
27,548
$
(4,004
)
(14.5
)%
Total expenses, net (A)
14,456
20,319
(5,863
)
(28.9
)%
Net investment income (A)
9,088
7,229
1,859
25.7
%
Net realized gain
–
20,879
(20,879
)
(100.0
)%
Net unrealized depreciation
(1,316
)
(10,235
)
8,919
(87.1
)%
Net increase in net assets resulting from operations (A)
$
7,772
$
17,873
$
(10,101
)
(56.5
)%
Net investment income per weighted-average common share (A)
$
0.25
$
0.20
$
0.05
25.0
%
Adjusted net investment income per weighted-average common share (B)
$
0.24
$
0.26
$
(0.02
)
(7.7
)%
Net increase in net assets resulting from operations per weighted-average common share (A)
$
0.21
$
0.49
$
(0.28
)
(57.1
)%
Cash distribution per common share from net investment income (C)
$
0.27
$
–
$
0.27
NM
Cash distribution per common share from net realized gains (C)
$
0.51
$
0.24
$
0.27
112.5
%
Weighted-average yield on interest-bearing investments
14.1
%
13.2
%
0.9
%
6.8
%
Total dollars invested
$
62,842
$
14,024
$
48,818
348.1
%
Total dollars repaid and collected from sales and recapitalization of investments
$
4,370
$
117,579
$
(113,209
)
(96.3
)%
Weighted-average shares of common stock outstanding – basic and diluted
36,908,943
36,837,381
71,562
0.2
%
Total shares of common stock outstanding
37,352,676
36,837,381
515,295
1.4
%
As of:
Total investments, at fair value
$
1,036,745
$
979,320
$
57,425
5.9
%
Fair value, as a percent of cost
103.9
%
104.3
%
(0.4
)%
(0.4
)%
Net assets
$
485,304
$
499,084
$
(13,780
)
(2.8
)%
Net asset value per common share
$
12.99
$
13.55
$
(0.56
)
(4.1
)%
Number of portfolio companies
27
25
2
8.0
%
NM = Not Meaningful
(A) Inclusive of $0.2 million, or $0.01 per weighted-average common share, of capital gains-based incentive fees reversed during the three months ended June 30, 2025 and $2.1 million, or $0.06 per weighted-average common share, of capital gains-based incentive fees accrued during the three months ended March 31, 2025, respectively. These fees were accrued in accordance with United States generally accepted accounting principles (“U.S. GAAP”), where such amounts were not contractually due under the terms of the investment advisory agreement for the respective periods. Also see discussion under Non-GAAP Financial Measure – Adjusted Net Investment Income below. (B) See Non-GAAP Financial Measure – Adjusted Net Investment Income, below, for a description of this non-GAAP measure and a reconciliation from Net investment income to Adjusted net investment income, including on a weighted-average per share basis. The Company uses this non-GAAP financial measure internally in analyzing financial results and believes it is useful to investors as an additional tool to evaluate ongoing results and trends for the Company. (C) Estimates of tax characterization made on a quarterly basis may not be representative of the actual tax characterization of distributions for the full year. Estimates made on a quarterly basis are updated as of each interim reporting date.
Highlights for the Quarter: During the quarter ended June 30, 2025, the following significant events occurred:
Portfolio Activity:
In May 2025, we invested $49.5 million in a new portfolio company, Smart Chemical Solutions, LLC (“Smart Chemical”), in the form of $35.7 million of secured first lien debt and $13.8 million of preferred equity. Smart Chemical, headquartered in Midland, Texas, is a leading provider of production chemicals for onshore oil and gas operators throughout the United States.
In May 2025, we invested $12.8 million in a new portfolio company, Sun State Nursery and Landscaping, LLC (“Sun State”), in the form of $9.8 million of secured first lien debt and $3.1 million of preferred equity. Sun State, headquartered in Jacksonville, Florida, is a leading commercial landscaping installation and maintenance provider in the Jacksonville area.
In June 2025, we restructured our investment in PSI Molded Plastics, Inc. As a result of the restructuring, we converted debt with a cost basis of $10.6 million into preferred equity.
Distributions and Dividends:
Paid an $0.08 per common share distribution to common stockholders in each of April, May and June 2025; and
Paid a $0.54 per common share supplemental distribution to common stockholders in June 2025.
At-the-market (“ATM”) Program Activity:
Sold 515,295 shares of our common stock under our common stock ATM program at a weighted-average gross price of $14.23 per share and raised approximately $7.2 million in net proceeds. These sales were above our then-current estimated NAV per share.
First Quarter Results: Net investment income for the quarter ended June 30, 2025 was $9.1 million, or $0.25 per weighted-average common share, compared to net investment income of $7.2 million, or $0.20 per weighted-average common share, for the quarter ended March 31, 2025. This increase was a result of a decrease in total expenses, net of credits, primarily due to a decrease in accruals for capital gains-based incentive fees and income-based incentive fees, a decrease in interest expense and an increase in credits from Adviser, partially offset by a decrease in total investment income in the current quarter.
Total investment income for the quarters ended June 30, 2025 and March 31, 2025 was $23.5 million and $27.5 million, respectively. The decrease quarter over quarter was due to a $3.5 million decrease in success fee income and $0.7 million decrease in dividend income that did not reoccur in the current quarter as the timing of such fee income is variable. These decreases were partially offset by a $0.1 million increase in interest income primarily due to the collection of $1.5 million of past due interest from a portfolio company previously on non-accrual status in the current quarter.
Total expenses, net of credits, for the quarters ended June 30, 2025 and March 31, 2025 was $14.5 million and $20.3 million, respectively. The decrease quarter over quarter was primarily due to a $2.3 million decrease in accruals for capital gains-based incentive fees in the current quarter, as a result of the net impact of realized and unrealized gains and losses, a $2.3 million decrease in income-based incentive fees and a $0.5 million decrease in interest expense due to decreased borrowings on the credit facility. The decrease was also due to a $0.4 million increase in credits from Adviser.
Net asset value per common share as of June 30, 2025 was $12.99, compared to $13.55 as of March 31, 2025. The decrease quarter over quarter was primarily due to $28.8 million, or $0.78 per common share, of distributions paid to common shareholders and $1.3 million, or $0.04 per common share, of net unrealized depreciation on investments and other. These decreases were partially offset by $9.1 million, or $0.25 per common share, of net investment income and $0.01 per common share of net accretive effect of equity offering.
Subsequent Events: After June 30, 2025, the following significant events occurred:
Significant Investment Activity:
In July 2025, we invested $67.6 million in a new portfolio company, Global GRAB Technologies, Inc. (“Global GRAB”), in the form of $46.5 million of secured first lien debt and $21.1 million of preferred equity. Global GRAB, headquartered in Franklin, Tennessee, is a leading provider of turnkey perimeter security and hostile vehicle mitigation systems, serving various government and commercial organizations.
Distributions and Dividends:
In July 2025, our Board of Directors declared the following monthly distributions to common stockholders:
Record Date
Payment Date
Distribution per Common Share
July 21, 2025
July 31, 2025
$
0.08
August 20, 2025
August 29, 2025
0.08
September 22, 2025
September 30, 2025
0.08
Total for the Quarter:
$
0.24
ATM program activity:
Subsequent to June 30, 2025, we sold 866,554 shares of our common stock under our common stock ATM program at a weighted-average gross price of $14.14 per share and raised approximately $12.1 million in net proceeds. These sales were above our then-current estimated NAV per share.
Non-GAAP Financial Measure – Adjusted Net Investment Income: On a supplemental basis, the Company discloses Adjusted net investment income, including on a weighted-average per share basis, which is a financial measure that is calculated and presented on a basis of methodology other than in accordance with GAAP. Adjusted net investment income represents net investment income, excluding capital gains-based incentive fees. The Company uses this non-GAAP financial measure internally in analyzing financial results and believes that this non-GAAP financial measure is useful to investors as an additional tool to evaluate ongoing results and trends for the Company. The Company’s investment advisory agreement provides that a capital gains-based incentive fee is determined and paid annually with respect to realized capital gains (but not unrealized appreciation) to the extent such realized capital gains exceed realized capital losses and unrealized depreciation on investments for such year. However, under GAAP, a capital gains-based incentive fee is accrued if realized capital gains and unrealized appreciation of investments exceed realized capital losses and unrealized depreciation of investments. Refer to Note 4 – Related Party Transactions in our Quarterly Report on Form 10-Q for further discussion. The Company believes that Adjusted net investment income is a useful indicator of operations exclusive of any capital gains-based incentive fees, as net investment income does not include realized or unrealized investment activity associated with the capital gains-based incentive fee.
The following table provides a reconciliation of net investment income (the most comparable GAAP measure) to Adjusted net investment income for the periods presented (dollars in thousands, except per share amounts; unaudited):
For the quarter ended
June 30, 2025
March 31, 2025
Amount
Per Share
Amount
Amount
Per Share
Amount
Net investment income
$
9,088
$
0.25
$
7,229
$
0.20
Capital gains-based incentive fee
(209
)
(0.01
)
2,129
0.06
Adjusted net investment income
$
8,879
$
0.24
$
9,358
$
0.26
Weighted-average shares of common stock outstanding – basic and diluted
36,908,943
36,837,381
Adjusted net investment income may not be comparable to similar measures presented by other companies, as it is a non-GAAP financial measure that is not based on a comprehensive set of accounting rules or principles and therefore may be defined differently by other companies. In addition, Adjusted net investment income should be considered in addition to, not as a substitute for, or superior to, financial measures determined in accordance with GAAP.
Conference Call: The Company will hold its earnings release conference call on Wednesday, August 13, 2025, at 8:30 a.m. Eastern Time. Please call (866) 373-3416 to enter the conference call. An operator will monitor the call and set a queue for any questions. A replay of the conference call will be available through August 20, 2025. To hear the replay, please dial (877) 660-6853 and use the playback conference number 13754185. The replay will be available beginning approximately one hour after the call concludes. The live audio broadcast of the Company’s quarterly conference call will also be available online at www.gladstoneinvestment.com. The event will be archived and available for replay on the Company’s website.
About Gladstone Investment Corporation: Gladstone Investment Corporation is a publicly traded business development company that seeks to make secured debt and equity investments in lower middle market businesses in the United States in connection with acquisitions, changes in control and recapitalizations. Information on the business activities of all the Gladstone funds can be found at https://www.gladstonecompanies.com/.
To obtain a paper copy of our Quarterly Report on Form 10-Q, filed today with the SEC, please contact the Company at 1521 Westbranch Drive, Suite 100, McLean, VA 22102, ATTN: Investor Relations. The financial information above is not comprehensive and is without notes, so readers should obtain and carefully review the Company’s Form 10-Q for the quarter ended June 30, 2025, including the notes to the consolidated financial statements contained therein.
The statements in this press release regarding potential future distributions, earnings and operations of the Company are “forward-looking statements.” These forward-looking statements inherently involve certain risks and uncertainties in predicting future results and conditions. Although these statements are based on the Company’s current plans that are believed to be reasonable as of the date of this press release, a number of factors could cause actual results and conditions to differ materially from these forward-looking statements, including those factors described from time to time in the Company’s filings with the Securities and Exchange Commission. The Company undertakes no obligation to publicly release the result of any revisions to these forward-looking statements that may be made to reflect any future events or otherwise, except as required by law.
Ginza Diamond Shiraishi Hong Kong is spotlighting the significance of the 鑽石戒指 (diamond ring) as both a cultural artifact and a contemporary symbol of enduring partnership. In a world where personal expression intersects with tradition, the diamond ring continues to maintain its place as a cornerstone of engagement and marital rituals, transcending generations and geographical boundaries.
While the origins of the diamond ring can be traced back centuries, its symbolic function remains firmly intact. The circular form traditionally represents eternity, unity, and the continuous nature of commitment, while the inclusion of a diamond—a stone associated with strength and clarity adds a layer of permanence and emotional depth. In the context of modern Hong Kong, where cultural heritage meets global aesthetics, the 鑽石戒指 diamond ring serves as both a personal statement and a shared tradition.
Ginza Diamond Shiraishi Hong Kong, known for its refined Japanese craftsmanship and subtle design ethos, approaches the diamond ring not merely as a decorative accessory but as a meaningful piece of ceremonial jewelry. Each ring is crafted with purpose, taking into account not only the technical aspects of cut, metal, and setting, but also the emotional narrative it is meant to carry throughout the wearer’s life.
The design philosophy underlying each 鑽石戒指 diamond ring produced by Ginza Diamond Shiraishi is rooted in a respect for both precision and restraint. Unlike trends that emphasize visual spectacle, the brand’s approach favors balance, harmony, and refined detail. This is achieved by drawing inspiration from elements in the natural world and traditional Japanese design principles, which prioritize subtle beauty and intentional form.
Each ring’s creation involves a careful selection of ethically sourced diamonds that meet strict quality standards. Beyond the standard “Four Cs” of cut, color, clarity, and carat, the diamonds are selected for their ability to harmonize with the design and overall feel of the piece. The goal is not to overwhelm the ring with a singular element, but to ensure that every component contributes to a coherent, enduring aesthetic.
In Hong Kong, where diversity of lifestyle and culture is reflected in personal milestones such as engagements and weddings, the 鑽石戒指 diamond ring continues to be a central feature of commitment ceremonies. Couples are increasingly attentive to the symbolism behind their ring choices. They seek not only beauty but meaning—something that speaks to their relationship’s unique journey while remaining grounded in cultural or familial values.
Recognizing this, Ginza Diamond Shiraishi Hong Kong provides a consultation experience that goes beyond standard retail interaction. Clients are welcomed into a quiet and respectful environment where discussions about design, tradition, and individual preferences can take place without pressure. The role of the consultant is not to persuade, but to guide, helping clients uncover the story they wish their diamond ring to reflect.
Technological advancements have also influenced how people approach the selection of 鑽石戒指 diamond rings. The ability to explore options online before entering a store has allowed couples to arrive more informed, and in many cases, more focused on the design elements that matter to them. Ginza Diamond Shiraishi Hong Kong supports this evolution with a digital platform that mirrors the brand’s attention to clarity and simplicity, ensuring that customers receive both inspiration and information in equal measure.
In addition to design and sourcing, durability remains a core concern. A 鑽石戒指 diamond ring is expected to be worn daily and to endure physical and emotional milestones alike. Ginza Diamond Shiraishi’s production process includes rigorous testing and quality control to ensure that each ring maintains both its form and integrity over time. Special attention is paid to the comfort of wear—particularly in how the ring fits on the hand and how the diamond setting withstands daily movement.
The cultural layer of meaning in the diamond ring remains highly relevant in Hong Kong’s social landscape. In many families, the exchange of rings is more than a private gesture; it is also a public commitment recognized by both immediate family and wider community. A diamond ring often becomes part of family heritage, passed down or commemorated across generations. Ginza Diamond Shiraishi Hong Kong acknowledges this by offering design lines that balance modern appeal with classic form—ensuring that the rings resonate in the present but remain timeless in the future.
The brand’s ongoing commitment to ethical practices also aligns with increasing consumer awareness. All 鑽石戒指 diamond rings are created using conflict-free diamonds and responsibly sourced metals. This transparency in the supply chain not only ensures compliance with international standards, but also reassures customers that the object they are investing in reflects values of fairness, sustainability, and human dignity.
In serving a market as multifaceted as Hong Kong, Ginza Diamond Shiraishi remains attentive to the shifting ways in which people engage with tradition. While some clients seek minimalist and contemporary interpretations, others favor more classical silhouettes. What unites all customers, however, is a desire for authenticity—something that connects emotion with craftsmanship, and aesthetics with intention.
As societal definitions of commitment continue to evolve, the diamond ring remains a powerful constant—a material symbol of immaterial values. Through its dedication to quality, design integrity, and cultural sensitivity, Ginza Diamond Shiraishi Hong Kong continues to play a quiet but enduring role in how modern couples mark their most significant promises.
DELRAY BEACH, FL / ACCESS Newswire / August 12, 2025 / Adolore BioTherapeutics, Inc., (“Company” or “Adolore”) announced that Roy Clifford Levitt, MD, Clinical Professor at the University of Miami, Principal Investigator and Program Director of the NIH, NINDS, HEAL UH3 Award supporting ADB-102 development for the treatment of chronic knee pain due to osteoarthritis, (“OA”), and founder and Executive Chairman of Adolore presented the Company’s breakthrough non-opioid gene therapy programs for chronic pain at the Next Generation Gene Therapy Vectors Summit on July 31, 2025 in Boston.
Dr. Levitt presented the latest safety and efficacy data on Adolore’s replication defective, disease-free, HSV viral vectors during his talk entitled: “Rethinking Vector Choice: Utilizing Optimized HSV to Enhance Safety & Efficacy”. He presented evidence of long-lasting (>7 months), profound analgesia (equivalent to high doses of opioids) for their HSV gene therapy with regional administration (single intra-articular knee joint injection) in model systems. Additional data demonstrated excellent cellular tropism (neuronal specificity), biodistribution, and shedding characteristics. Dr. Levitt also highlighted how regional administration minimizes off-target effects, improving safety, efficacy, and minimizes immunogenicity.
Adolore is advancing two preclinical development programs: a lead program for knee pain due to OA and a program for erythromelalgia, (“EM”), an orphan neuropathic pain indication for which there are no FDA-approved treatments. EM is a rare, heritable, chronic and debilitating pain disease.
In model systems, replication-defective, disease-free, herpes simplex virus (rdHSV) gene therapy expressing an analgesic carbonic anhydrase-8 (CA8*) peptide variant corrects somatosensory hyperexcitability by activating Kv7 voltage-gated potassium channels, thereby producing profound, long-lasting analgesia. Adolore has achieved proof-of-concept in animal models, validating the mechanism of action in knee pain from OA and EM.
About Adolore BioTherapeutics, Inc.
Adolore BioTherapeutics, Inc., is a biotechnology company focused on developing novel therapies for treating chronic pain using a revolutionary intra-cellular replication-defective HSV (rdHSV) drug delivery platform that is disease-free, non-toxic, and permits localized peripheral nervous system delivery of proprietary biotherapeutics. This rdHSV gene therapy technology incorporates an established re-dosing strategy and an excellent safety profile. HSV vectors are known for their stability and prolonged gene expression, providing an excellent basis for the long-term treatment of chronic pain conditions and neurological disorders. Our best-in-class CA8* programs are long-acting, locally acting gene therapies that are opioid-free Disease-Modifying Anti-Pain therapies (DMAPs) designed to treat many forms of chronic pain as well as therapies for epilepsy and hearing loss.
Leveraging its innovative gene therapy vectors expressing CA8* analgesic peptides (ADLR-1001), Adolore is currently advancing two preclinical development programs: ADB-101 for the treatment of patients’ chronic pain caused by erythromelalgia, an orphan disease, and ADB-102, their lead program for the treatment of patients with chronic pain caused by knee OA. Based on substantial compelling preclinical data generated to date, the Company is progressing these programs toward IND filings and first-in-human clinical studies. Adolore has two additional programs available for partnering: ADB-104 for Drug-Resistant Refractory Focal Epilepsy, ADB-105 for Acute Severe Hearing Loss and ADB-106 for Chronic Eye Pain.
For more information, visit adolore.com.
Forward-Looking Statements
To the extent this announcement contains information and statements that are not historical, they are forward-looking statements within the meaning of the federal securities laws. You can identify forward-looking statements by the use of the words “believe,” “expect,” “anticipate,” “intend,” “estimate,” “project,” “will,” “should,” “may,” “plan,” “intend,” “assume” and other expressions which predict or indicate future events and trends and which do not relate to historical matters. You should not rely on forward-looking statements because they involve known and unknown risks, uncertainties, and other factors, some of which are beyond the control of the Company. These risks and uncertainties include, but are not limited to, those associated with drug development. These risks, uncertainties, and other factors may cause the actual results, performance, or achievements of the Company to be materially different from the anticipated future results, performance, or achievements expressed or implied by the forward-looking statements.
Safety First Training Ltd. has been a leader in safety education for more than 30 years. They focus on workplace safety, especially through their Forklift Operator Certification Program. This program is available in Toronto, Mississauga, the Greater Toronto Area, and all across Ontario. It is tailored to equip workers with the skills needed to operate forklifts safely while meeting Canadian safety standards. Courses from Safety First Training Toronto are vital for companies looking to improve their safety measures and follow necessary regulatory requirements, which are key for both efficiency and worker well-being.
The program provided by Safety First Training combines both classroom learning and hands-on practice. This ensures that forklift operators not only know the technical details but also understand safety procedures. The course covers equipment inspections, effective load handling, identifying and reducing workplace hazards, and following safe operational strategies. These elements help create a safer work environment, reduce accidents, and enable workers to do their jobs well.
Participants must pass a series of written and practical tests to prove their understanding and skill in operating forklifts safely. Those who pass earn a certification according to CSA Standard B335-15. This certification is a recognized credential for forklift operator qualifications and matches both provincial and federal standards. Its recognition highlights the program’s alignment with national safety rules, contributing to nationwide safety compliance.
“Forklifts are vital to many industries, but without proper training, they can pose serious safety risks,” said Kevin Mork, CEO of Safety First Training Ltd. “Our program gives operators the confidence and competence to work safely, while helping organizations maintain compliance and reduce workplace incidents.”
The training is designed for a wide range of participants, such as newcomers to forklift operations, experienced workers needing recertification, and industry employees in warehousing, manufacturing, construction, and logistics. The program covers various types of forklifts, and experienced instructors adjust the course to suit different categories, ensuring a comprehensive understanding and skills development. For companies interested in self-sufficiency, Safety First Training also offers a Train the Trainer program which allows companies to develop their in-house safety experts.
Safety First Training Toronto is dedicated to offering flexible training options. They provide scheduling choices and on-site training to allow companies to incorporate certification into their operations without significant downtime. This flexibility supports companies in keeping up with their work demands while boosting their workforce’s safety skills.
The process for enrolling in Safety First Forklift Training Toronto‘s certification program is simple. Companies can tailor the training according to their needs, considering factors such as group size, experience level, or location. This adaptability and commitment to quality training have built client trust across various industries. By addressing specific business needs, Safety First Training solidifies its role as a dependable partner in workplace safety.
To learn more about the Forklift Operator Certification Program and see how Safety First Training can help achieve safety aims across different fields, visit the company’s website. Businesses can find out more about the program’s benefits and how it helps maintain a culture of safety within organizations.
Silverback AI Chatbot has announced an enhancement to its conversational automation platform with a focus on expanding the capabilities of its AI Agents system. The new update supports a growing shift in how companies are leveraging AI Automation to manage customer and operational interactions through autonomous, multi-step workflows that traditionally required live human involvement.
The development represents a continued evolution of the AI Chatbot landscape moving from simple, scripted tools to systems that can independently process tasks with logic, memory, and outcome-based reasoning. Unlike conventional chat interfaces limited to keyword triggers or one-off replies, Silverback’s AI Agents are engineered to understand task objectives, track progress, and take action over time, often across multiple systems or channels.
At the core of this shift is the concept of agentic architecture. AI Agents, as deployed in Silverback’s framework, are designed to operate with goal persistence. Once assigned a task such as booking an appointment, qualifying a lead, or responding to a support ticket the agent proceeds through a structured sequence of steps, adapting to new inputs as they occur. These tasks may span multiple user sessions, involve complex decision trees, or require accessing and updating external systems like CRMs, calendars, or knowledge bases.
Silverback’s AI Chatbot platform integrates these agents into a broader system of AI Automation that combines natural language understanding with programmable business logic. This integration allows for AI-driven conversations that do more than just answer questions they can initiate, track, and complete real tasks in real time.
The agents function by orchestrating different components, including large language models for language comprehension, secure APIs for data handling, and memory modules that preserve user context over time. This configuration enables the chatbot to shift from reactive interaction to proactive task execution. Whether it’s following up with a customer days after their initial inquiry or routing information between departments, the agent acts as a self-contained operator within defined business parameters.
The update is designed to meet growing demand from small to mid-sized businesses that require intelligent automation but do not have in-house AI development capabilities. By removing technical barriers to entry, the platform allows users to configure their own AI Agents without needing to write or maintain complex codebases. Users can define goals, connect systems, and customize workflows through an accessible interface.
In application, the AI Agents are being adopted for diverse use cases across industries. A professional services firm may use an agent to onboard clients and collect required documentation. An online retailer might configure agents to handle common post-purchase queries, return processes, or shipping updates. Each agent is tailored to the specific workflow requirements of the business deploying it.
A defining characteristic of these agents is their ability to manage continuity in asynchronous interactions. Unlike legacy AI Chatbot models that lose context after a session ends, Silverback’s AI Agents retain memory and can resume conversations where they left off. This continuity allows them to guide users through extended processes that may not be completed in one sitting, while ensuring data consistency and task integrity.
Security and governance are built into the system’s architecture. As AI Automation becomes more deeply integrated into customer-facing and internal systems, Silverback has focused on ensuring compliance with global data protection standards. Data passed through the AI Chatbot interface is encrypted and processed in monitored environments, with audit capabilities available to business users for transparency.
Performance optimization is another key feature of the AI Agents system. Through built-in analytics, businesses can monitor how each agent is performing—tracking metrics such as task completion rates, customer satisfaction, and conversation drop-offs. This data allows for iterative improvements to workflows and decision trees, resulting in a smarter, more effective automation model over time.
The release reflects wider industry trends pointing toward AI Chatbot platforms becoming more task-centric rather than solely conversational. AI Agents are not designed merely to simulate dialogue, but to deliver tangible outcomes through autonomous operations. As such, their deployment touches on areas of operations, customer service, marketing, and internal administration.
Silverback’s strategy includes continued development of cross-functional capabilities for its agents. While current implementations focus on external interactions—such as customer engagement and sales enablement—the roadmap includes potential extensions to internal business support roles. Future versions of AI Agents may assist with employee onboarding, document generation, or real-time reporting for teams operating in hybrid or remote models.
The company has also made available a library of onboarding resources, configuration templates, and technical support channels to assist non-technical users. These tools are intended to accelerate deployment timelines and improve usability, allowing businesses to focus on defining task outcomes rather than managing infrastructure.
As businesses continue to explore the possibilities of AI Automation, tools like Silverback’s AI Agents provide a bridge between high-level strategic goals and day-to-day operational execution. By combining persistence, adaptability, and system integration within a conversational framework, these agents mark a new phase in the practical deployment of AI technology.
Analysts observing the shift note that agent-based AI Chatbot systems are playing an increasingly central role in modern business environments. The move from static chat tools to intelligent agents capable of executing workflows represents not only a technological upgrade but also a fundamental shift in how companies can structure digital labor.
The growing functionality of AI Agents is also prompting broader discussions around oversight, responsibility, and value alignment in automation. While the agents can operate independently, Silverback has emphasized the importance of maintaining human visibility into critical operations, ensuring that business rules, ethics, and user trust are upheld.
With the ongoing expansion of AI capabilities, Silverback’s development of its AI Agents system positions it as part of the next wave of intelligent automation tools. Businesses looking to streamline tasks, enhance user experience, and reduce operational friction now have access to tools that are both technically advanced and operationally accessible.
FreeFlyer® modeling confirms feasibility of new orbit families offering persistent lunar access for surveillance, navigation and communication.
LANHAM, MD / ACCESS Newswire / August 12, 2025 / a.i. solutions, a leading provider of mission-critical aerospace engineering services and software, and Coorbital Inc., an emerging startup specializing in cislunar astrodynamics, announced the successful modeling and validation of a newly discovered family of “tulip-shaped” orbits, a first in the field of cislunar astrodynamics. This innovative research, originally developed by Dr. Darin Koblick in collaboration with Texas A&M University, was modeled and verified using a.i. solutions’ FreeFlyer® astrodynamics software.
Recently published in the Journal of Astronautical Sciences, these orbit families, characterized by their distinctive multi-lobed, flower-like geometry, were introduced as “tulip-shaped orbits.” They leverage the gravitational interplay between Earth and the Moon to enable mission profiles previously considered infeasible. Unlike traditional NRHOs or Distant Retrograde Orbits, tulip-shaped orbits enable sidereal resonant coverage with more flexible geometry and lower ΔV demands, offering broad utility for lunar surveillance, communications, navigation and space domain awareness.
“Working with Coorbital Inc., we used FreeFlyer to validate the performance and station-keeping feasibility of tulip-shaped orbits,” said Dr. Brian McCarthy, senior astrodynamicist at a.i. solutions supporting the NASA Gateway Program. “These orbits offer persistent lunar coverage with minimal ΔV and have real potential to support both commercial and government cislunar operations.”
This work aligns with key national priorities to advance lunar exploration and space surveillance capabilities. It supports efforts such as the U.S. Air Force Research Laboratory’s Oracle family, the U.S. Space Force’s Golden Dome, and NASA’s LunaNet architecture. “We have a great deal to learn when it comes to operating, navigating and communicating from cislunar space,” said Col. Jeremy Raley, Director of the AFRL Space Vehicles Directorate.
Employing a novel station-keeping control strategy, Koblick and McCarthy successfully maintained all fourteen families of sidereal resonant tulip-shaped orbits with mean annual ΔV costs between 6-15 m/s, well within operational feasibility for current and future spacecraft.
“This represents a major advancement in astrodynamics research and underscores the value of industry collaboration in advancing both government and commercial space exploration and security missions,” said Koblick. The successful validation of tulip-shaped orbits sets the stage for a near-term demonstration mission, an opportunity to test and confirm their operational advantages. With continued collaboration and real-world testing, tulip-shaped orbits could soon play a foundational role in building secure, scalable infrastructure across the Earth-Moon system.
About a.i. solutions Inc. a.i. solutions is a leading aerospace engineering firm providing mission-critical software, engineering services, and operational support to civilian, commercial, and national security space missions. With a history spanning over two decades, the company is committed to delivering reliable solutions that ensure mission success. Learn more at http://www.ai-solutions.com.
About Coorbital Inc. Coorbital Inc. is a Los Angeles based aerospace startup pioneering next-generation space and missile defense technologies. The company develops advanced solutions for ISR, SDA, hypersonic threats, and interplanetary missions. With a focus on innovation and national security, Coorbital is helping shape the future of defense and space exploration. Learn more at http://www.coorbital.com.
Contact Information
Doug Stewart Vice President of Strategic Marketing, Appleton doug@appletoncreative.com 407-246-0092 ext. 1
Now Offering Veterinary Hemodialysis, Therapeutic Plasma Exchange, and Hemoperfusion
BEND, OR / ACCESS Newswire / August 12, 2025 / The Veterinary Referral Center of Central Oregon (VRCCO) is proud to announce the addition of advanced Extracorporeal Therapies, including Hemodialysis, Therapeutic Plasma Exchange, and Hemoperfusion, to its suite of specialized veterinary services. VRCCO is honored to be among the few facilities in the US to offer these cutting-edge treatments that provide new hope for pets suffering from acute kidney injuries, chronic kidney disease, immune-mediated diseases, and life-threatening toxicities.
Hemodialysis serves as an “artificial kidney” by filtering a pet’s blood to remove harmful substances such as waste, toxins, and excess fluids. While it does not directly heal the kidneys, it provides a vital window of time for recovery, while significantly improving comfort and quality of life for the pet during this critical period. Hemodialysis is most commonly used for acute kidney injuries, severe electrolyte imbalances, fluid overload, and certain toxicities.
Therapeutic Plasma Exchange (TPE) is a procedure designed to remove harmful substances from a pet’s plasma, replacing it with donor plasma. This therapy is particularly effective in managing severe immune-mediated conditions such as immune-mediated hemolytic anemia (IMHA) and myasthenia gravis, as well as certain toxicities. Pets may experience rapid improvement, particularly with immune-mediated diseases that are unresponsive to conventional treatments.
Hemoperfusion involves filtering a pet’s blood through a cartridge containing activated charcoal or similar materials to adsorb toxins. This technique is especially valuable in cases of NSAID overdoses (e.g., ibuprofen, carprofen) or exposure to other harmful substances where no antidote exists. Treatments are generally completed within 2-4 hours, and a single session is often sufficient if administered before organ damage occurs.
VRCCO utilizes the same advanced dialysis machines and materials used in human medicine, ensuring the highest standards of care. Throughout treatments, patients are continuously monitored for vital parameters including blood clotting times, fluid balance, hematocrit, electrolytes, and cardiac health, with personalized attention from their care team. Pet Parents should also be aware of the following while considering these therapies:
Comfort & Compassionate Care: Dialysis treatments are not painful. Pets rest comfortably on soft bedding under the continuous care and observation of VRCCO’s specialized team. Sedation is rarely required.
Patient Size & Suitability: Most companion animals, regardless of size, can be safely treated. VRCCO’s in-house blood bank ensures the availability of transfusions if necessary.
Prognosis & Expectations: Treatment outcomes are highly variable and depend on the severity and cause of the condition. Some pets may require only a few treatments, while others may need ongoing therapy.
Early Intervention is Critical: Starting dialysis before severe complications arise, such as fluid overload or organ dysfunction, dramatically improves the likelihood of a positive outcome.
The Veterinary Referral Center’s board-certified specialists encourage pet parents and referring veterinarians to consult with them to determine whether these therapies are appropriate for individual cases. In many situations, time is a critical factor and early intervention can be life-saving. To learn more about Extracorporeal Therapies or VRCCO’s comprehensive specialty services, please contact the Veterinary Referral Center of Central Oregon at 541-209-6960 or info@vrcvet.com.
GREENSBORO, NC—Jeffrey Segal, MD, JD, the founder of Medical Justice and a nationally recognized medico‑legal authority, supports a newly issued Position Statement from the American Academy of Neurology, American Epilepsy Society, and Epilepsy Foundation of America that revisits when—and under what circumstances—people who experience seizures may safely resume driving. The Statement, “Seizures, Driver Licensure, and Medical Reporting Update,” replaces a 2007 version and urges states to anchor their licensing rules in clinical evidence while preserving the physician‑patient relationship.
Dr. Segal dissects the Position Statement’s findings in his blog post “How Soon Can Patients Who Experience a Seizure Resume Driving, If at All?”, noting that the societies’ research confirms a “modest but real” increase in motor‑vehicle accidents (MVAs) associated with epileptic seizures, yet also shows that fatal‑crash risk is LOWER than that posed by alcohol use disorder and by young, inexperienced drivers.
“The data overturn the notion that every person with a seizure disorder represents an outsized menace on the road,” Dr. Segal explained. “Risk clearly decreases the longer a patient remains seizure‑free, and that decline becomes meaningful at about three months. A universal requirement that people wait six, nine, or twelve months after a seizure looks more punitive than protective.”
Dr. Segal endorses the Position Statement’s central recommendation: a minimum three‑month seizure‑free interval, with flexibility for state medical‑review boards to shorten or lengthen that period based on individualized factors such as medication adherence, nocturnal‑only seizure patterns, or a history of treatment‑resistant epilepsy.
“Blanket prohibitions do little to enhance public safety if they push patients into unlicensed driving or discourage them from being honest with their doctors,” he said. “A tailored, evidence‑driven approach respects patient autonomy and still allows regulators to intervene when red flags appear, like recurrent seizures despite aggressive therapy or clear non‑compliance with medication.”
Equally significant, according to Dr. Segal, is the Position Statement’s stance on reporting. The societies conclude that mandatory physician reporting of every seizure does not reduce crash rates, yet does increase unlicensed driving and patient reluctance to disclose essential information. The Statement therefore recommends placing primary responsibility on patients to self‑report seizure activity to their departments of motor vehicles (DMVs) and recommends granting clinicians legal authority—but not an obligation—to notify authorities when a patient poses a clear hazard.
“Imposing a mandate to report every seizure creates an adversarial dynamic,” Dr. Segal commented. “Physicians become reluctant enforcers, patients clam up, and genuine public‑safety threats go underground. Authorizing, but not compelling, reporting, coupled with robust immunity for clinicians who in good faith choose to report or not report, strikes the right balance.”
The Position Statement also urges states to keep licensing criteria in regulations or guidelines rather than hard‑coding them into statutes. “That’s an important procedural safeguard,” Dr. Segal observed. “Evidence evolves, and regulators need agility to adjust rules as new data emerge without waiting for a legislature to reconvene.”
He added that DMVs should retain ultimate decision‑making authority, even when they consult treating practitioners. “Physicians supply the facts; medical advisory boards weigh those facts against risk‑tolerance thresholds set by the public and its elected representatives.”
Commercial and professional drivers warrant more stringent scrutiny, the societies acknowledge, because of greater road exposure and larger vehicles. Dr. Segal agrees but cautions against overgeneralization. “A long‑haul trucker who has been seizure‑free for years under stable therapy should not be lumped with someone who had a breakthrough tonic‑clonic episode last month,” he said. “Regulations must reflect real‑world risk, not fear.”
Functional (psychogenic non‑epileptic) seizures, which lack the electrical abnormalities of epilepsy yet still impair consciousness and motor control, also fall under the new guidance. The statement recommends that drivers experiencing these events receive counseling and restrictions comparable to those for epileptic seizures until more data emerge. Dr. Segal supports this inclusion: “Ignoring functional seizures would create a dangerous loophole. The societies wisely err on the side of safety while signaling the need for further study.”
Ultimately, Dr. Segal views the Position Statement as a timely nudge for states whose rules still rely on decades‑old assumptions. “It is long overdue,” he said. “States should update their regulations to adopt a three‑month minimum seizure‑free interval, allow nuanced adjustments, and place reporting responsibility primarily on drivers. We cannot legislate perfect safety, but we can remove arbitrary barriers that penalize well‑controlled patients and undermine candid doctor‑patient dialogue.”
About Medical Justice: Founded by Jeffrey Segal, MD, JD, Medical Justice has guided physicians through the complex intersection of medicine, law, and public policy for nearly two decades. Healthcare professionals seeking advice on medico‑legal risk management are invited to schedule a complimentary 15‑minute consultation online and explore Medical Justice’s protection plans for doctors, which provide wide-ranging strategies from in-office risk management protocols to online reputation management.
