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With the industry’s largest network of sites, Florence sets a new benchmark for AI-enabled study startup, workflow automation, and operational risk management.

ATLANTA, GA / ACCESS Newswire / October 23, 2025 / Florence Healthcare reinforced its position as the global leader in clinical trial operations with a major milestone: Florence Trial Operations Platform now connects 65,000 study sites spanning more than 600 sponsors across 90+ countries, forming the industry’s largest network. Recognized as the #1 clinical trial technology for six consecutive years, Florence continues to set the standard for startup speed, workflow automation, and operational risk management across sponsor study portfolios.

“Florence was built to bring sponsors and sites into a shared operational space,” said Ryan Jones, CEO of Florence Healthcare. “First, we fully digitized startup to eliminate manual bottlenecks and paper workflows. Now, we’re using AI to enhance speed and augment intelligence across 65,000 study sites globally – arming sponsors with portfolio-wide operational visibility so they can anticipate trial risk, act on insights, and drive execution on the ground.”

Solving the $1 million per study problem

While digital-first sites set new standards for operational speed and efficiency, much of the industry still remains offline. Only 30% of global sites currently use an eISF, leaving roughly 200,000 sites dependent on inefficient paper processes for study startup, document collection and storage, regulatory process management, monitoring and closeout.

This lack of digitization costs sponsors an estimated $1 million per study in lost productivity, rework, quality and compliance risk.

Florence is closing this digital divide through the fastest growing clinical research network of 65,000 study sites and 600+ sponsors. By digitizing 100% of operational workflows, Florence sets the standard for startup speed, operational cost reduction, and risk control.

The results are compelling:

• Up to 70% faster last mile study startup operations compared to the average site startup time for a Top 10 global pharmaceutical sponsor.

• $141M annual operational cost takeout by automating site readiness workflows, based on active daily users and total hours saved per year across Florence’s study site network.

• 51% increase in eTMF QA pass rates from 65% to 98.7%, due to built-in operational audits and automated compliance checks to control risk.

Shaping the Future of Study Operations

Florence is embedding AI across the study lifecycle to unlock operational data intelligence, recommend next-best actions, strengthen risk control, and improve operating efficiency.

Site Identification & Feasibility

Drawing on the industry’s largest network of site intelligence, Florence enables sponsors and CROs to identify the most qualified sites by therapeutic area, geography, and performance, while AI-assisted feasibility surveys ensure faster, more accurate completion.

Study Startup

AI-enabled contracting and document exchange between eTMF and eISF automates SSU document exchange, while generative AI redlining shortens contract review cycles, compares terms in seconds, and dramatically reduces time to activation.

Remote Monitoring

AI-powered reporting surfaces early risk signals from operational audit trails and site data, providing real-time visibility and enabling proactive intervention. These insights minimize the need for on-site visits and ensure trials stay on schedule.

Together, these advancements move sponsors and CROs from manual oversight to intelligent execution across global study portfolios. Through its open API network, Florence rapidly integrates and extends its trial operation capabilities to other eClinical partner systems.

Florence AI operates at the speed of trust, ensuring every study remains fully aligned with FDA, EMA, HIPAA, GDPR, EU Annex 11, ICH E6 (R3), and GCP standards.

All capabilities will be available in December 2025.

Join the Movement: Research Revolution 2025

Florence will showcase its newest capabilities at Research Revolution 2025, the company’s annual global event (October 26-28, 2025) bringing together sponsors, CROs, and research sites. Be part of the global revolution. Watch it live at: https://researchrevolutionsummit.com/live/

About Florence Healthcare

Florence is a purpose-built platform that connects sponsors and sites to accelerate clinical trials, improve operational capacity, and reduce risk. Designed for scale, Florence streamlines workflows, enhances collaboration, and delivers real-time visibility across studies-empowering research teams to move faster, stay inspection-ready, and increase trial throughput with fewer resources.

Contact Information

Seema Sheth-Voss
seema.shethvoss@florencehc.com
(888) 829-0896

SOURCE: Florence Healthcare

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LISBON, PT AND WEST PALM BEACH, FL / ACCESS Newswire / October 23, 2025 / USPA Global today announced that U.S. Polo Assn., the official sports brand of the United States Polo Association (USPA), has been awarded two prestigious Stevie^® Awards from the 22^nd Annual International Business Awards^® (IBA).

U.S. Polo Assn. was celebrated during an elegant gala event at the Corinthia Hotel in Lisbon, Portugal, on Friday, October 10, attended by leadership from USPA Global and the brand’s strategic partners in the region. The global event hosted over 350 guests from more than 30 nations, including many of the world’s top companies and Stevie winners, including Coca-Cola, Starbucks, Lenovo, Kendra Scott, IBM, and Turkish Airlines.

The brand’s winning entries included a Gold Stevie Award for ‘Achievement in International Expansion’ and a Silver Stevie Award in ‘Celebration Event’ for the 2024 Paris Games Polo Challenge campaign. The multi-billion-dollar, sport-inspired global brand received high scores from the judges over all submissions in these very competitive global growth categories. Accepting the two trophies on stage were Stacey Kovalsky, Vice President, Global PR and Communications, and Yesim Ilgun for USPA Global; Franco Zuccon, CEO, Eurotrade; Augusto Bonetto, CEO, Bonis; Alessia Lana, Incom; Filippo Peroni and Enrica Cova, Eastlab.

“For U.S. Polo Assn. to win both Gold and Silver Stevie Awards from the 22^nd Annual International Business Awards is a tremendous recognition of our brand’s global prowess and creative strength,” said J. Michael Prince, President and CEO of USPA Global, the company that manages the multi-billion-dollar U.S. Polo Assn. brand. “We are especially proud to be recognized for our international expansion strategy, which includes efforts from all of U.S. Polo Assn.’s strategic global partners, and for the Paris Games Polo Challenge, a one-of-a-kind global campaign that celebrated the heritage of the sport on an historic, world sports stage.”

The Gold Award for ‘Achievement in International Expansion’ acknowledges U.S. Polo Assn.’s $2.5 billion in global retail sales across 190 countries, with more than 1,200 branded retail stores and a strong e-commerce presence in more than 50 countries in 20 different languages. The Silver Award for ‘Celebration Event’ highlights the brand’s groundbreaking Paris Games Polo Challenge 2024, a centennial celebration and sanctioned tribute match between the USA and France at the Polo Club du Domaine Chantilly. Both awards, altogether, strengthen U.S. Polo Assn.’s authentic connection to the sport of polo and consumers worldwide.

The International Business Awards are widely recognized as the world’s premier business awards program. The 2025 IBAs attracted entries from organizations spanning nearly 80 nations and territories, with more than 3,800 nominations from organizations of all sizes and virtually every industry submitted across a wide range of categories this year. Stevie Award winners were determined by the average scores of more than 250 executives worldwide who participated in the three-month judging process.

Details about the 22^nd Annual International Business Awards and the complete list of 2025 Stevie Award winners are available at StevieAwards.com/IBA.

About U.S. Polo Assn. and USPA Global

U.S. Polo Assn. is the official sports brand of the United States Polo Association (USPA), the largest association of polo clubs and polo players in the United States, founded in 1890 and based at the USPA National Polo Center (NPC) in Wellington, Florida. This year, U.S. Polo Assn. celebrates 135 years of sports inspiration alongside the USPA. With a multi-billion-dollar global footprint and worldwide distribution through more than 1,200 U.S. Polo Assn. retail stores as well as thousands of additional points of distribution, U.S. Polo Assn. offers apparel, accessories, and footwear for men, women, and children in more than 190 countries worldwide. The brand sponsors major polo events around the world, including the U.S. Open Polo Championship®, held annually at NPC in The Palm Beaches, the premier polo tournament in the United States. Historic deals with ESPN in the United States, TNT and Eurosport in Europe, and Star Sports in India now broadcast several of the premier polo championships in the world, sponsored by U.S. Polo Assn., making the thrilling sport accessible to millions of sports fans globally for the very first time.

U.S. Polo Assn. has consistently been named one of the top global sports licensors in the world alongside the NFL, PGA Tour, and Formula 1, according to License Global. In addition, the sport-inspired brand is being recognized internationally with awards for global growth. Due to its tremendous success as a global brand, U.S. Polo Assn. has been featured in Forbes, Fortune, Modern Retail, and GQ as well as on Yahoo Finance and Bloomberg, among many other noteworthy media sources around the world.

For more information, visit uspoloassnglobal.com and follow @uspoloassn.

USPA Global is a subsidiary of the United States Polo Association (USPA) and manages the multi-billion-dollar sports brand, U.S. Polo Assn. USPA Global also manages the subsidiary, Global Polo, which is the worldwide leader in polo sport content. To learn more, visit globalpolo.com or Global Polo on YouTube.

###

Contact Information

Stacey Kovalsky
VP, Global PR and Communications
skovalsky@uspagl.com
+001.561.790.8036

Kaela Drake
PR & Communications Specialist
kdrake@uspagl.com
+001.561.461.8596

SOURCE: U.S. Polo Assn.

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CAMBRIDGE, MA / ACCESS Newswire / October 23, 2025 / Moderna, Inc. (Nasdaq:MRNA) today announced that it will host its Investor Event – Analyst Day at 9:00 a.m. ET on Thursday, November 20, 2025.

The event will include presentations from management discussing Moderna’s development and commercial strategy and key business considerations.

A live webcast of the presentation will be available under “Events and Presentations” in the Investors section of the Moderna website

Webcast: investors.modernatx.com.

A replay of the webcast will be archived on Moderna’s website for at least 30 days following the presentation.

About Moderna

Moderna is a leader in the creation of the field of mRNA medicine. Through the advancement of mRNA technology, Moderna is reimagining how medicines are made and transforming how we treat and prevent disease for everyone. By working at the intersection of science, technology and health for more than a decade, the company has developed medicines at unprecedented speed and efficiency, including pioneering work on COVID-19 vaccines.

Moderna’s mRNA platform has enabled the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and autoimmune diseases. With a unique culture and a global team driven by the Moderna values and mindsets to responsibly change the future of human health, Moderna strives to deliver the greatest possible impact to people through mRNA medicines. For more information about Moderna, please visit modernatx.com and connect with us on X (formerly Twitter), Facebook, Instagram, YouTube and LinkedIn.

Media Contacts

Investors:
Lavina Talukdar
Senior Vice President & Head of Investor Relations
617-209-5834
Lavina.Talukdar@modernatx.com

SOURCE: Moderna, Inc.

View the original press release on ACCESS Newswire

NEW YORK, NY / ACCESS Newswire / October 23, 2025 / There are two kinds of tightening in business. The kind you do because you have to, and the kind you do because you’re getting ready to move faster. SMX (NASDAQ:SMX) just made it very clear which kind this is.

Following a consolidation that leaves the company with roughly one million shares outstanding, SMX isn’t playing defense; it’s bracing for acceleration. The move, often misread by retail as reactionary, is in truth a recalibration. The kind that clears clutter, simplifies the map, and tells the market, “We’re not here to blend in. We’re here to break through.”

The Springboard Effect

With a share count that now looks more like a startup than a global supply-chain pioneer, SMX has done something remarkably rare in the small-cap universe: it’s set the table for torque. A million shares means a tighter float, a cleaner structure, and a sharper translation between achievement and value. Every new contract, partnership, or revenue milestone will now echo louder on a per-share basis.

It’s the corporate equivalent of cutting body fat while adding muscle. Same company, same DNA, but a very different level of velocity.

And for short sellers, that’s where the danger begins. When a float this small meets a catalyst this large, the math stops being linear; it becomes financially lethal from a risk-reward perspective. Shorting a company with only about a million shares in the wild and a growing list of global partners isn’t a trade. It’s a dare. The kind that ends with margin calls and blinking screens.

The Proof Economy Gets Real

If you’ve followed SMX for any length of time, you know its partnerships read like a map of modern manufacturing: Singapore’s A*STAR, CETI (France), Tradepro Group, BT-Systems, REDWAVE, Bio-Packaging Pte Ltd., Aegis, and a widening circle that reaches from the EU’s recycling corridors to Australia’s resource backbone. Add collaborations touching Skypac and Continental, and you have a roster that looks less like a startup deck and more like a blueprint for industrial reform.

These are not vanity collaborations. They’re validation points in a trillion-dollar problem-authenticating and verifying the materials that feed global commerce. The same invisible thread that proves a luxury brand’s leather is real can also verify that a recycled polymer actually came from a sustainable source. SMX doesn’t just mark materials; it gives them memory.

And memory is power.

Recalibrating for the Next Ascent

Let’s be honest: reverse splits get a bad rap. They’re usually seen as a red flag. But context matters. SMX’s recapitalization wasn’t about compliance; it was about optimization. SMX’s new structure resets its optics for institutional investors, reduces volatility from excessive micro-trading, and aligns perfectly with the next phase of growth, built on scalability.

Think of it as tightening the laces before a sprint. This isn’t retreat-it’s recoil.

Because underneath the corporate mechanics, the core story hasn’t changed. SMX is still the company digitizing matter itself and connecting block-chain and AI to the physical world through molecular proof. Its Plastic Cycle Token (PCT)–a verifiable, tradable unit of sustainable value-continues to gain traction as governments and corporations seek a tangible measure, not just an offset.

Proof Is Still the Currency

Markets may take a moment to digest the new structure, but fundamentals have a funny way of catching up to math. SMX’s tightened share base, global partnerships, and regulatory tailwinds form a collaborative cocktail that could make this next chapter the most dynamic yet. With just about a million shares on the field, every move will now matter exponentially more.

That’s not a reset; it’s a potential springboard. And anyone betting short may want to step back from that coil. Because when the world is pivoting toward proof and the company driving it has a microscopic float, shorting that story isn’t bold; it’s a master class in bad timing.

About SMX

As global businesses face new and complex challenges relating to carbon neutrality and meeting new governmental and regional regulations and standards, SMX is able to offer players along the value chain access to its marking, tracking, measuring and digital platform technology to transition more successfully to a low-carbon economy.

Forward-Looking Statements

The information in this press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “will,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements in this press release may include, for example: matters relating to the Company’s fight against abusive and possibly illegal trading tactics against the Company’s stock; successful launch and implementation of SMX’s joint projects with manufacturers and other supply chain participants of gold, steel, rubber and other materials; changes in SMX’s strategy, future operations, financial position, estimated revenues and losses, projected costs, prospects and plans; SMX’s ability to develop and launch new products and services, including its planned Plastic Cycle Token; SMX’s ability to successfully and efficiently integrate future expansion plans and opportunities; SMX’s ability to grow its business in a cost-effective manner; SMX’s product development timeline and estimated research and development costs; the implementation, market acceptance and success of SMX’s business model; developments and projections relating to SMX’s competitors and industry; and SMX’s approach and goals with respect to technology. These forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties. Accordingly, forward-looking statements should not be relied upon as representing views as of any subsequent date, and no obligation is undertaken to update forward-looking statements to reflect events or circumstances after the date they were made, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. As a result of a number of known and unknown risks and uncertainties, actual results or performance may be materially different from those expressed or implied by these forward-looking statements. Some factors that could cause actual results to differ include: the ability to maintain the listing of the Company’s shares on Nasdaq; changes in applicable laws or regulations; any lingering effects of the COVID-19 pandemic on SMX’s business; the ability to implement business plans, forecasts, and other expectations, and identify and realize additional opportunities; the risk of downturns and the possibility of rapid change in the highly competitive industry in which SMX operates; the risk that SMX and its current and future collaborators are unable to successfully develop and commercialize SMX’s products or services, or experience significant delays in doing so; the risk that the Company may never achieve or sustain profitability; the risk that the Company will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all; the risk that the Company experiences difficulties in managing its growth and expanding operations; the risk that third-party suppliers and manufacturers are not able to fully and timely meet their obligations; the risk that SMX is unable to secure or protect its intellectual property; the possibility that SMX may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties described in SMX’s filings from time to time with the Securities and Exchange Commission.

EMAIL: info@securitymattersltd.com

SOURCE: SMX (Security Matters) Public Limited

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Global live streaming viewership grew 13% year-over-year to 9.6B hours watched during Q3 2025, reflecting the highest Q3 viewership ever across all live-streaming platforms

FRISCO, TX / ACCESS Newswire / October 23, 2025 / Stream Hatchet, the leading provider of data analytics for the live streaming and gaming ecosystem and wholly-owned subsidiary of GameSquare Holdings (NASDAQ:GAME), (“GameSquare”, or the “Company”), has released its Q3 2025 Live Streaming Trends Report. The report reveals key insights into the evolution of the global live streaming market across gaming, esports, and entertainment.

Access to the report is available at: https://streamhatchet.com/reports/q3-2025-live-streaming-trends-report/

“Live streaming continues to expand beyond gaming as it becomes a powerful force for the future of live entertainment,” said Justin Kenna, CEO of GameSquare. “With TikTok Live surpassing Twitch in total hours watched and events like the Esports World Cup and Kai Cenat’s Mafiathon setting new benchmarks for engagement, we’re witnessing a massive reallocation of attention. These trends validate our belief that creators and interactive formats are driving the next generation of media.”

Key Insights from Stream Hatchet’s Q3 2025 Report:

• Twitch dropped below 50% market share for the first time ever, partially due to viewbotting crackdowns (but remains the most-viewed platform)

• TikTok Live data is in, and the mobile platform brought in 9.2B hours watched in Q3 2025 compared to 4.6B for Twitch – a major shift in perception for where audiences find streaming

• The Esports World Cup grew stronger, with the Saudi-backed global gaming event reaching 168M hours watched – up 73% from 2024

• Subathon 2025 reached record levels with Kai Cenat as the big winner: His Mafiathon 3 marathon stream brought in 71% of all Subtember subs

• Live-streaming is the place for sports: As just one example, FC Barcelona hit 3.2M viewers for their match against Como 1907

For more information on Stream Hatchet and insight into the esports and streaming markets, please visit their website at www.streamhatchet.com.

About GameSquare Holdings, Inc.

GameSquare (NASDAQ:GAME) is a cutting-edge media, entertainment, and technology company transforming how brands and publishers connect with Gen Z, Gen Alpha, and Millennial audiences. With a platform that spans award-winning creative services, advanced analytics, and FaZe Clan Esports, one of the most iconic gaming organizations, we operate one of the largest gaming media networks in North America. As a digital-native business, GameSquare provides brands with unparalleled access to world-class creators and talent, delivering authentic connections across gaming, esports, and youth culture. Complementing our operating strategy, GameSquare has developed an innovative treasury management program designed to generate yield and enhance capital efficiency, reinforcing our commitment to building a dynamic, high-performing media company at the intersection of culture, technology, and next-generation financial innovation.

To learn more, visit www.gamesquare.com.

About Stream Hatchet

Stream Hatchet delivers real-time, actionable insights into the gaming and live-streaming ecosystem across 16 platforms. From performance benchmarking to campaign ROI and influencer intelligence, Stream Hatchet empowers game publishers, brands, agencies, and tournament organizers with the industry’s most granular data and reporting tools.

For more information visit www.streamhatchet.com.

Forward-Looking Information

This news release contains “forward-looking information” and “forward-looking statements” (collectively, “forward-looking statements”) within the meaning of the applicable securities legislation. All statements, other than statements of historical fact, are forward-looking statements and are based on expectations, estimates and projections as at the date of this news release. Any statement that involves discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, assumptions, future events or performance (often but not always using phrases such as “expects”, or “does not expect”, “is expected”, “anticipates” or “does not anticipate”, “plans”, “budget”, “scheduled”, “forecasts”, “estimates”, “believes” or “intends” or variations of such words and phrases or stating that certain actions, events or results “may” or “could”, “would”, “might” or “will” be taken to occur or be achieved) are not statements of historical fact and may be forward-looking statements. In this news release, forward-looking statements relate, among other things, to: the Company’s future performance, revenue, growth and profitability; and the performance of the live streaming market . These forward-looking statements are provided only to provide information currently available to us and are not intended to serve as and must not be relied on by any investor as, a guarantee, assurance or definitive statement of fact or probability. Forward-looking statements are necessarily based upon a number of estimates and assumptions which include, but are not limited to: the Company’s ability to grow their business and being able to execute on their business plans, the Company being able to complete and successfully integrate acquisitions, the Company being able to recognize and capitalize on opportunities and the Company continuing to attract qualified personnel to supports its development requirements. These assumptions, while considered reasonable, are subject to known and unknown risks, uncertainties, and other factors which may cause the actual results and future events to differ materially from those expressed or implied by such forward-looking statements. Such factors include, but are not limited to: the Company’s ability to achieve its objectives, the Company successfully executing its growth strategy, the ability of the Company to obtain future financings or complete offerings on acceptable terms, failure to leverage the Company’s portfolio across entertainment and media platforms, dependence on the Company’s key personnel and general business, economic, competitive, political and social uncertainties. These risk factors are not intended to represent a complete list of the factors that could affect the Company which are discussed in the Company’s most recent MD&A. There can be no assurance that forward-looking statements will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on the forward-looking statements and information contained in this news release. GameSquare assumes no obligation to update the forward-looking statements of beliefs, opinions, projections, or other factors, should they change, except as required by law.

Corporate Contact
Lou Schwartz, President
Phone: (216) 464-6400
Email: ir@gamesquare.com

Investor Relations
Andrew Berger
Phone: (216) 464-6400
Email: ir@gamesquare.com

Media Relations
Chelsey Northern / The Untold
Phone: (254) 855-4028
Email: pr@gamesquare.com

SOURCE: GameSquare Holdings, Inc.

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Watch the Discovery Channel’s “Let’s Take It Outside” program this Sunday, Oct. 26, and discover what makes Florida wild

SAINT AUGUSTINE, FLORIDA / ACCESS Newswire / October 23, 2025 / Live Wildly – the Florida non-profit working to help people fall in love with nature – will be featured in the upcoming episode of the Discovery Channel’s “Let’s Take It Outside” program, starring angler and outdoor enthusiast Misty Wells.

The episode will air at 5:30 a.m. Sunday, Oct. 26, on the Discovery Channel, and viewers will get the chance to meet two of Live Wildly’s dedicated team members – Senior Director of Conservation Dr. Thomas Eason and Events Producer Michelle Yepez – as they boat across the Florida Keys, catch lobster and discuss what makes Florida’s lands and waters so special. It is also available to watch on demand starting Oct. 26 on Discovery GO and shortly thereafter on Discovery Plus.

“What a blast to explore Florida’s natural areas with Misty Wells,” said Eason. “We not only got the chance to see the amazing and diverse species that call Florida home, but we experienced firsthand why Florida is known as one of the greatest outdoor recreational spots in the world.”

Live Wildly is the official sponsor of the sixth season of “Let’s Take It Outside.” Live Wildly’s work to protect Florida’s lands and waters will be highlighted throughout the season, and viewers will be invited to “Join the Movement” to explore, connect with and protect wild Florida.

“Partnering with the Live Wildly Foundation and its mission is the perfect partnership as we share the same goal to keep Florida wild,” said Wells. “Given the growth and development pressures in Florida, every acre saved for Florida’s future is a win. I am proud to be part of the Live Wildly team and future.”

Along with hosting “Let’s Take It Outside,” Wells also is a Live Wildly Outdoor Adventurist and will be working with Live Wildly to encourage people to get outside and connect with nature.

“Misty’s passion for Florida’s lands and waters makes her the ideal ambassador for this movement to protect nature, bringing new audiences into the fold and inspiring them to care about conservation,” said Live Wildly’s CEO Lisa Shipley. “People protect what they love, and working together, we are helping people fall in love with nature.”

Live Wildly’s mission is the long-term protection of Florida’s lands and waters, starting with a permanently conserved Florida Wildlife Corridor. The Corridor, established in 2021, is an 18-million-acre network of lands and waters stretching from the Everglades to the Panhandle. It not only provides habitat for almost 2,000 different species – including the iconic Florida panther, manatees, and the Gopher tortoise – but also supports more than 100,000 jobs and generates $30 billion in annual revenue through recreation, tourism, agriculture and other industries.

To learn more, visit www.LiveWildly.com

SOURCE: Live Wildly Foundation

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VANCOUVER, BC / ACCESS Newswire / October 23, 2025 / North Shore Uranium Ltd. (TSXV:NSU) (“North Shore” or the “Company“) is pleased to announce that it has met its final earn-in obligation for the West Bear property (“West Bear“)under an option agreement dated April 18, 2022 (as amended, the “West Bear Option Agreement“) with Gem Oil Inc. (“Gem Oil“), giving the Company the right to acquire a 75% interest in West Bear. West Bear consists of four mining claims totaling 3,927 hectares at the eastern margin of the Athabasca Basin in Saskatchewan.

To satisfy the final $50,000 payment for West Bear, the Company issued 263,157 common shares (the “Option Shares“) at a deemed price of $0.19 per share to Gem Oil. The Options Shares were issued in accordance with the West Bear Option Agreement and are subject to a statutory hold period under applicable Canadian securities laws and a TSX Venture Exchange hold period, both expiring four months and one day from the date of issuance (February 23, 2026). Upon completion of this payment, North Shore has earned a 75% interest in West Bear and a joint venture will be formed with North Shore holding a 75% interest and Gem Oil holding a 25% interest. Gem Oil will be granted a 2% net smelter returns royalty (“NSR“), of which North Shore may purchase 1% for $1,000,000 at any time. North Shore retains the right to acquire the remaining 25% interest in West Bear by paying Gem Oil $200,000 in cash and issuing $200,000 in North Shore common shares within 90 days of delivering the Initial Interest Notice to Gem Oil. If North Shore does not exercise this right within the 90-day period, or fails to complete the acquisition, a participating joint venture will be formed as described above.

West Bear is located approximately 35 km southeast of the Cigar Lake uranium mine, and 50 km south of the McClean Lake uranium mill. The West Bear uranium and cobalt-nickel deposits held by Uranium Energy Corp. (“UEX/UEC“) are located just north of the property (Figure 1 below). The unconformity between the Athabasca Basin sandstone and the underlying basement rocks crosses the western portion of the property (Figure 1). West Bear saw significant uranium exploration activity between the 1960s and 2015, with a total of 15 exploration holes being drilled, including three by Denison in 2015. Historical exploration data evaluated by the Company includes high-resolution electromagnetic airborne geophysical surveys. In 2022 North Shore completed a gravity-magnetic-radiometric airborne survey over West Bear. The Company has selected several targets that warrant further exploration and evaluation of all exploration data is ongoing.

ABOUT NORTH SHORE

The nuclear power industry is in growth mode as more nuclear power will be required to meet the world’s ambitious CO₂ emission-reduction goals and the needs of new power-intensive technologies like AI. In this environment, new discoveries of economic uranium deposits could be very valuable, especially in established uranium-producing jurisdictions like Saskatchewan and New Mexico. North Shore is well-positioned to become a major force in exploration for economic uranium deposits. The Company is working to achieve this goal by exploring its Rio Puerco project in the Grants Uranium District of New Mexico and the Falcon and West Bear properties at the eastern margin of the Athabasca Basin in Saskatchewan. In addition, the Company continues to evaluate quality opportunities in the United States and Canada to complement its portfolio of uranium properties.

Figure 1. West Bear property and neighboring property positions. Source: Saskatchewan government database on September 15, 2025 and company disclosure. This figure contains information about properties adjacent to West Bear which North Shore does not have the right to explore. Investors are cautioned that mineralization on adjacent properties is not necessarily indicative of mineralization at West Bear.

Technical information on the West Bear property is provided in the 2023 technical report entitled “Technical Report for the West Bear Property, Saskatchewan, Canada” filed under the profile of North Shore Uranium at www.sedarplus.ca.

QUALIFIED PERSON

Mr. Brooke Clements, MSc, P.Geol., a Qualified Person as defined by National Instrument 43-101 – Standards of Disclosure for Mineral Projects and the President and CEO of North Shore, has reviewed and approved the scientific and technical disclosure in this press release.

ON BEHALF OF THE BOARD

Brooke Clements,
President, Chief Executive Officer and Director

For further information please contact: Brooke Clements, President, Chief Executive Officer and Director

Telephone: 604.536.2711
Email: b.clements@northshoreuranium.com
www.northshoreuranium.com

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Forward-Looking Statements

This news release contains forward-looking statements relating specifically to the West Bear Property earn-in and the Company’s broader exploration strategy. Forward-looking statements in this release include: the formal completion of the West Bear property earn-in from Gem Oil Inc.; the issuance of common shares to satisfy the final property payment; the formation of a joint venture with Gem Oil and the grant of a net smelter returns royalty; North Shore’s right to acquire the remaining 25% interest in West Bear; the identification of several exploration targets at West Bear; the Company’s belief that it is well-positioned to become a major force in exploration for economic uranium deposits; the Company’s ongoing work to achieve this goal by exploring the Rio Puerco project in New Mexico and the Falcon and West Bear properties in Saskatchewan; and the Company’s continued evaluation of additional uranium opportunities in the United States and Canada. These statements are subject to specific risks and uncertainties, including: the risk that the West Bear Property earn-in may not be completed as anticipated; the risk that the joint venture may not be formed or operated as planned; the risk that North Shore may not exercise its right to acquire the remaining 25% interest; the risk that identified exploration targets may not yield economically viable mineral deposits upon further exploration or drilling; the potential for delays or changes in exploration plans due to environmental conditions, permitting requirements, or logistical challenges in accessing certain areas of the West Bear Property; and the reliance on historical data and previous exploration results, which may have limitations or uncertainties that affect current interpretations. Forward-looking statements are frequently characterized by words such as “plan”, “project”, “appear”, “interpret”, “coincident”, “potential”, “confirm”, “suggest”, “evaluate”, “encourage”, “likely”, “anomaly”, “continuous” and variations of these words as well as other similar words or statements that certain events or conditions “could”, “may”, “should”, “would” or “will” occur. These statements are subject to various risks and uncertainties that may cause actual results to differ materially from those anticipated or implied, including, but not limited to: the speculative nature of mineral exploration and development projects; the ability to obtain necessary permits and approvals; changes in project plans and parameters; variations in mineral grades and recovery rates; accidents, labour disputes and other risks of the mining industry; the availability of funding on terms acceptable to the Company; delays in obtaining governmental approvals or financing; fluctuations in uranium and other metal prices; and other factors described in the Company’s public disclosure documents. There may be other factors that cause actual results, performance, or achievements to differ materially from those anticipated or implied by the forward-looking statements. Any forward-looking statement speaks only as of the date on which it is made and, except as may be required by applicable securities laws, the Company disclaims any intent or obligation to update any forward-looking statement, whether as a result of new information, future events, or results or otherwise. Forward-looking statements are not guarantees of future performance and undue reliance should not be put on such statements due to the inherent uncertainty therein. Any forward-looking statements contained in this news release are expressly qualified in their entirety by this cautionary statement.

SOURCE: North Shore Uranium Ltd.

View the original press release on ACCESS Newswire

New findings highlight Telomir-1’s impact on CASP8 and GSTP1, two critical genes that regulate cell death and glutathione-based detoxification pathways often disrupted in cancer.

MIAMI, FLORIDA / ACCESS Newswire / October 23, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) (“Telomir” or the “Company”), a pre-clinical biotechnology company developing therapies that target the epigenetic roots of cancer, aging, and age-related disease, today reported new preclinical data from an in vivo study in mice bearing human aggressive prostate cancer tumors evaluating DNA-methylation changes in two key defense genes – CASP8 and GSTP1 – following treatment with oral Telomir-1, Rapamycin, chemotherapy, and combination regimens.

Apoptosis (“kill”) and detoxification (“clean”) pathways are two of the body’s fundamental defense systems against cancer initiation and progression, and Telomir-1’s observed modulation of these pathways through DNA-methylation control may represent an important area of ongoing scientific evaluation in oncology research.

Overview of Findings

The study examined DNA methylation, a central epigenetic process that helps determine whether genes are active or silenced. In this model, baseline tumor samples exhibited DNA hypermethylation of CASP8 and GSTP1, a pattern often associated with reduced activity in genes involved in apoptosis and detoxification.

• CASP8 (Apoptosis Pathway)
  CASP8 helps initiate programmed cell death. Telomir-1 treatment was associated with reduced methylation of the CASP8 promoter at Day 10 and 21 relative to vehicle and chemotherapy group, suggesting potential reactivation of apoptotic pathway control.

• GSTP1 (Detoxification and Glutathione Pathway)
  GSTP1 encodes glutathione S-transferase Pi 1, an enzyme that uses glutathione (GSH) – one of the body’s most important natural antioxidants – to neutralize reactive oxygen species and chemical stress. Telomir-1 was associated with decreased DNA-methylation of GSTP1 compared with vehicle and chemotherapy, consistent with partial restoration of this critical detoxification and antioxidant defense system.

• Chemotherapy Alone
  Chemotherapy did not appear to reduce methylation of either gene, consistent with prior observations that certain cytotoxic agents can reinforce methylation stress – a process that may contribute to taxane resistance (reduced tumor response to chemo drugs like paclitaxel) driven by transcriptional and epigenetic rewiring.

• Combination of Chemotherapy + Telomir-1
  When Telomir-1 was administered with chemotherapy, both CASP8 and GSTP1 showed lower methylation than with chemotherapy alone, suggesting that Telomir-1 may help counteract chemotherapy related epigenetic silencing in this setting.

Why These Pathways Matter in Cancer Biology

Apoptosis and detoxification represent two of the body’s most fundamental defense systems against cancer initiation and progression.

• Apoptosis – the “Kill System”
  This pathway allows damaged or abnormal cells to self-destruct before they proliferate. In many cancers, genes such as CASP8 become silenced through abnormal DNA methylation, preventing programmed cell death and enabling tumor survival and resistance to therapy.

• Detoxification – the “Clean System”
  The GSTP1 glutathione axis helps remove oxidative and chemical stress that accumulates during inflammation, environmental exposure, or treatment. When DNA sequence for GSTP1 is hypermethylated and silenced, cells lose part of this antioxidant capacity, leading to higher oxidative stress and DNA instability. Supporting glutathione related detoxification may reduce the cellular conditions that favor tumor persistence and therapy resistance.

By addressing both apoptotic and detoxification imbalances through DNA methylation modulation, Telomir-1 may engage two complementary mechanisms commonly disrupted in cancer biology.

Rapamycin Comparison

At earlier observation points (Day 10), Rapamycin – an mTOR-pathway inhibitor – was associated with an initial reduction in DNA methylation for both genes. This observation aligns with Rapamycin’s indirect influence on cellular metabolism and oxidative stress, which can temporarily affect DNA methylating enzyme activity.
By Day 21, methylation levels partially rebounded, suggesting that the effect may have been transient and metabolically driven rather than a direct epigenetic reset.

Telomir-1, by contrast, was associated with a progressive and more sustained decrease in methylation through Day 21. Unlike Rapamycin, Telomir-1 is believed to interact with epigenetic regulatory enzymes that add or remove methyl groups from DNA and histones, which may contribute to the durability of its observed effects in this preclinical model.

Interpretation

Collectively, these preclinical observations indicate that Telomir-1 influenced two complementary cellular pathways – apoptosis and detoxification – through DNA methylation modulation not observed with chemotherapy and more sustained than that seen with Rapamycin.
The data suggest Telomir-1 may act at the level of epigenetic enzyme regulation, whereas Rapamycin’s effects appear secondary to metabolic signaling.
Further studies are planned to clarify these mechanisms and their potential relevance for oncology research.

Scientific Perspective

“This preclinical work, which supports earlier studies with Telomir-1 on DNA methylation in cancer, helps differentiate the epigenetic modulation observed with Telomir-1 from the indirect metabolic effects of Rapamycin,” said Dr. Itzchak Angel, CSA at Telomir. “By evaluating DNA methylation dynamics in apoptosis and detoxification pathways, we are building a scientific framework for understanding how Telomir-1 may help restore epigenetic balance in cancer models.“

CEO Perspective

“Our goal is to develop medicines that don’t just treat what cancer becomes but help reset the biology that lets it begin. Telomir-1 may represent that next frontier.“
– Erez Aminov, CEO, Telomir

About Telomir Pharmaceuticals

Telomir Pharmaceuticals (NASDAQ:TELO) is a pre-clinical stage biotechnology company developing therapies designed to target the root epigenetic mechanisms underlying cancer, aging, and degenerative disease. The Company’s lead candidate, Telomir-1, has demonstrated activity in preclinical studies involving modulation of DNA and histone methylation patterns, which may contribute to balanced gene expression, cellular function, and genomic stability.
For more information, please visit www.telomirpharma.com.

Cautionary Note Regarding Forward-Looking Statements

This press release, statements of Telomir’s management or advisors related thereto, and the statements contained in the news story linked in this release contain “forward-looking statements,” which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications, and the safety of Telomir-1.

Any forward-looking statements in this press release are based on Telomir’s current expectations, estimates and projections only as of the date of this release. These and other risks concerning Telomir’s programs and operations are described in additional detail in its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, which are on file with the SEC and available at www.sec.gov. Telomir explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.

Contact Information

Helga Moya
info@telomirpharma.com
(786) 396-6723

SOURCE: Telomir Pharmaceuticals, Inc

View the original press release on ACCESS Newswire

Unified architecture connects classrooms, offices, and data centers with centralized control and predictable performance

SALT LAKE CITY, UTAH / ACCESS Newswire / October 23, 2025 / FatPipe, Inc. (NASDAQ:FATN) announced the completion of a 210+ site SD-WAN rollout for a large U.S. school district under a $1.4 million contract. The project brings all campuses, administrative offices, and data centers onto a single FatPipe SD-WAN design intended to provide reliable connectivity for instruction, testing, voice, and video.

“We are excited to complete a 210+ site SD-WAN deployment for a large school district and to welcome another district to our growing K-12 customer base,” said Sanch Datta, President and CTO of FatPipe. “A single architecture across campuses helps technology teams scale policy, speed up troubleshooting, and focus on the classroom experience.”

The district standardized on FatPipe’s controller-led architecture to streamline turn-up and ongoing operations. Zero-touch provisioning and template-based configuration helped accelerate site activations while maintaining consistency across school types. Application-aware routing and intelligent path selection keep learning platforms responsive during peak periods.

“Executing deployments of this scale underscores FatPipe’s ability to deliver complex network transformations efficiently and at enterprise scale,” added Datta. “Each new rollout expands our footprint and deepens relationships with organizations that depend on secure, high-performance connectivity. As we grow our base of long-term customers across public and private sectors, we believe FatPipe is well-positioned to capture a larger share of the rapidly expanding SD-WAN and SASE markets and create sustained value for our shareholders.”

Forward-Looking Statements

Certain statements contained in this press release, including statements relating to the Company’s expectations regarding the completion, timing and size of its proposed public offering and listing may constitute forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements can generally be identified by our use of forward-looking terminology such as “may,” “will,” “expect,” “intend,” “anticipate,” “estimate,” “believe,” “continue,” or other similar words. Readers are cautioned not to place undue reliance on these forward-looking statements, which are based on management’s current expectations and are inherently subject to various risks, uncertainties, assumptions, or changes in circumstances that are difficult to predict or quantify. These risks and uncertainties include, but are not limited to, risks and uncertainties associated with the consummation of the offering and other risks described in FatPipe’s registration statement on Form S-1, as it may be amended from time to time. Except as required by law, FatPipe expressly disclaims a duty to provide updates to forward-looking statements, whether as a result of new information, future events or other occurrences.

About FatPipe

FatPipe pioneered the concept of software-defined wide area networking (SD-WAN) and hybrid WANs that eliminated the need for cooperation from ISPs and allow companies and service providers to control multi-link network traffic worldwide. FatPipe has now pioneered cost-effective, advanced single-stack cybersecurity for on-premise deployments that significantly improve network and cybersecurity for SMBs.

FatPipe obtained 13 U.S. patents related to multipath, software-defined networking. FatPipe products are sold by 100+ resellers worldwide.

For more information, visit www.FatPipe.com.

Follow us on X @FatPipe_Inc.

Company Contact Info
Vikrant Ragula
Director of Investor Relations
+1 801.683-5656 x 1140
Investor.ir@FatPipeinc.com
press132@FatPipeinc.com

SOURCE: FatPipe Networks

View the original press release on ACCESS Newswire