Smarter Air & Electrical, a South East Queensland-based air conditioning and electrical contractor, has announced enhancements to its core service offerings, reflecting a continued commitment to quality, transparency, and long-term customer satisfaction. The company, which services Brisbane, the Gold Coast, Redlands, Ipswich, North Brisbane, and the Sunshine Coast, has expanded its service processes to deliver greater efficiency, more transparent communication, and stronger aftercare support for residential and commercial clients.
The development is part of the company’s ongoing efforts to refine its services in response to customer feedback and industry changes. Since its establishment in 2019, Smarter Air & Electrical has become known for ducted air conditioning installations, split system solutions, servicing, repairs, replacements, and a range of electrical services. With over 480 verified five-star reviews, the business has positioned itself as one of the most trusted names in the region.
According to co-owner Davis Row, the recent enhancements were designed to improve both the installation and service experience. “From the beginning, Smarter Air & Electrical has aimed to provide consistent workmanship and open communication. By enhancing our service processes, we are reinforcing those values while meeting the needs of a growing customer base. These changes will ensure that every project, no matter the size, is delivered with the highest level of professionalism and care,” Row said.
Among the updated features of the company’s services is a stronger emphasis on upfront transparency. Fixed, itemised quotes have long been part of the business model, but the process has been further refined to ensure customers receive comprehensive details before work begins. This improvement reduces uncertainty and provides clients with a clear understanding of costs, inclusions, and expectations.
Another key element of the enhanced services is the focus on aftercare. Customers now receive expanded post-installation walkthroughs, which include not only a demonstration of controls but also detailed guidance on filter care, zoning management, and scheduling. This approach has been welcomed by homeowners seeking reassurance that they can manage their new systems effectively.
The business continues to differentiate itself through in-house installation crews serving Brisbane and the Gold Coast. Unlike many contractors that rely heavily on subcontractors, Smarter Air & Electrical ensures consistency and accountability by employing its own technicians. This operational model has been maintained as part of the service enhancements, guaranteeing that workmanship standards remain aligned with the company’s values.
In addition to installation improvements, Smarter Air & Electrical has reinforced its servicing and maintenance programs. Technicians now provide more comprehensive reporting on system performance, enabling customers to make informed decisions about ongoing care. Preventative maintenance remains a cornerstone of the company’s approach, aimed at improving efficiency, reducing running costs, and extending the lifespan of equipment.
The company’s unique selling points, including its exclusive partnerships with leading HVAC brands, remain central to the enhancements. As a Mitsubishi Diamond Dealer, Smarter Air & Electrical has access to advanced systems and training that provide customers with reliable products tailored to Queensland’s climate. These brand partnerships ensure that the company continues to deliver durable, energy-efficient systems supported by manufacturer backing.
Co-owner Phillip Crawley explained that the service refinements are part of a broader vision for the business. “Customer satisfaction has always been the measure of success for Smarter Air & Electrical. By building on our core strengths, we are ensuring that customers continue to receive services that are both reliable and forward-looking. The enhancements reflect our goal of being a trusted provider that communities can rely on long into the future,” Crawley said.
The enhancements also highlight the company’s response to the growing demand for energy efficiency. Rising energy costs and increasing temperatures across Queensland have made well-designed air conditioning systems a priority for homeowners. Smarter Air & Electrical’s focus on zoning technology, ductwork design, and professional load calculations positions it to meet this demand effectively.
Business highlights supporting the announcement include a dual-branch structure in Yatala and Little Mountain, four dedicated installation crews, and a 10-vehicle fleet that services the wider South East Queensland region. The company has become one of the area’s largest suppliers of ducted systems while continuing to provide split systems, servicing, replacements, and electrical installations such as security cameras.
Customer feedback continues to validate the company’s direction. Verified reviews consistently reference punctuality, workmanship quality, and clear communication, qualities that have been reinforced under the new service approach. Many reviews also highlight the professionalism of technicians and the clarity of post-installation explanations, elements that are now formally embedded in the updated customer experience.
The decision to enhance services reflects Smarter Air & Electrical’s growth trajectory since 2019 and its recognition that maintaining standards is essential as demand increases. By combining operational refinements with existing strengths such as its workmanship guarantee and exclusive brand partnerships, the company is positioning itself for continued leadership in the South East Queensland HVAC market.
Smarter Air & Electrical’s announcement marks a significant development for both existing and future customers, who can expect a more comprehensive service experience with every installation or maintenance project. The company has made clear that its goal is to set benchmarks for professionalism, reliability, and customer care within the region.
For further information about the company’s enhanced services, interested parties may visit the official website of Smarter Air & Electrical.
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For more information about Smarter Air Pty Ltd, contact the company here:
Smarter Air Pty Ltd (Brisbane) Davis Row & Phillip Crawley 730672396 info@smarterair.com.au
McDonough, Georgia – October 23, 2025 – PRESSADVANTAGE –
Arrowhead Clinic Chiropractor McDonough has released comprehensive educational resources addressing a critical health concern affecting thousands of Georgia accident victims each year – the delayed onset of injury symptoms following vehicular collisions. Read more here: https://arrowheadclinic.weebly.com/blog/why-mcdonough-accident-victims-need-immediate-chiropractic-care-understanding-delayed-injury-symptoms. This comprehensive resource details the critical first 72 hours following an accident and explains diagnostic procedures used to identify hidden injuries.
The McDonough chiropractic facility reports an increasing number of patients seeking treatment days or weeks after accidents, often experiencing complications that could have been prevented with immediate care. The clinic indicates that many accident victims who delay treatment develop chronic pain conditions within six months of their initial injury.
Dr. Robbyn Keating, lead chiropractor at Arrowhead Clinic McDonough, explains the physiological reasons behind delayed symptom presentation. “The human body releases adrenaline and endorphins during traumatic events like car accidents, which can mask pain and injury symptoms for hours or even days,” stated Dr. Keating. “This natural response, while protective in the immediate aftermath, often leads patients to believe they are uninjured when micro-tears in muscles, spinal misalignments, and internal inflammation are already developing.”
The clinic has documented common delayed symptoms, including neck pain and stiffness appearing 24 to 72 hours post-accident, progressive headaches developing over several days, shoulder and upper back discomfort emerging gradually, and neurological symptoms such as numbness or tingling in extremities manifesting days after the initial trauma. Additional concerns include cognitive symptoms like difficulty concentrating and mood changes that may not be immediately associated with physical trauma. Accident victims can learn more here about the importance of immediate evaluation: .
The McDonough facility maintains same-day appointment availability specifically for accident victims, recognizing that early intervention significantly impacts long-term recovery outcomes. Treatment protocols focus on addressing both apparent and potential hidden injuries through advanced diagnostic imaging, comprehensive physical examinations, and personalized treatment plans designed to prevent acute injuries from developing into chronic conditions.
Dr. Keating emphasizes the long-term implications of delayed treatment. “When patients wait weeks to seek care, simple soft tissue injuries can develop into complex chronic pain syndromes requiring extensive rehabilitation. Early intervention allows us to address inflammation, restore proper spinal alignment, and prevent the formation of problematic scar tissue that can limit mobility and cause ongoing discomfort.”
A recent McDonough Arrowhead Clinic patient review highlighted the importance of immediate care, with one patient noting significant improvement after seeking treatment within 24 hours of their accident, compared to previous experiences where delayed treatment led to months of unnecessary pain and limited mobility.
Arrowhead Clinic has served Georgia communities for over 48 years, specializing in same day accident-related injury treatment and recovery. The organization operates multiple locations throughout Georgia and South Carolina, providing comprehensive chiropractic care, diagnostic services, and assistance with insurance documentation for accident victims. The McDonough location continues this tradition of accessible, evidence-based care for individuals recovering from auto accidents and other traumatic injuries.
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For more information about Arrowhead Clinic Chiropractor McDonough, contact the company here:
Arrowhead Clinic Chiropractor McDonough Dr. Robbyn Keating (770) 637-6261 info@arrowheadclinics.com 2154 GA-20, McDonough, GA 30253
Big Easy Air Conditioning has announced the availability of free estimates for both residential and commercial air conditioning services throughout New Orleans and surrounding communities. This change enables clients to obtain a detailed, professional quote before committing to maintenance, repairs, or new installations. The company’s stated goal is to make air conditioning services accessible and transparent while providing property owners with the information required to make informed decisions about their HVAC systems before proceeding with any technical work.
Clients who contact Big Easy Air Conditioning are invited to begin with a consultation call, during which they can discuss the specifics of their property or business climate needs. The service process begins with a comprehensive on-site inspection that includes assessment of insulation and the current air conditioning setup. Based on these findings, Big Easy Air Conditioning provides a summary of required repairs, maintenance tasks, or installations and delivers a tailored estimate with projected costs—completely free of charge and with no obligation.
Once an agreement is reached, the company’s fully licensed and insured technicians will do the repair, maintenance, or installation according to industry standards. All workmanship is verified through a concluding inspection to ensure systems are operating as designed. The business’s follow-up and customer support policy includes post-service access for customers who have questions or require further assistance, with the objective of fostering long-term client relationships and ensuring overall satisfaction after the job is complete.
Big Easy Air Conditioning provides a diverse range of technical solutions, including central air system installation and repairs, duct services, ductless options, and evaporative cooler setup. The service menu accommodates both residential homes and commercial buildings, supported by a roster of experienced professionals. Maintenance plans, available to customers who seek ongoing care, are emphasized as a practical way to prolong the lifespan and efficiency of cooling equipment, averting breakdowns and improving energy performance across the service life of each unit.
Both routine and emergency air conditioning needs are addressed through 24/7 service availability, designed to minimize system outages regardless of the time of day or week. Same-day service for certain urgent scenarios is also available, as indicated by the company’s customer information, targeting both immediate repairs and comfort restoration for clients facing unexpected HVAC disruptions.
Customer statements drawn from service experiences highlight timeliness, technical proficiency, and affordability as reasons for selecting Big Easy Air Conditioning for ongoing needs. User reviews share accounts of thorough diagnostics and quick repair turnarounds, and mention consistent pricing practices, including the absence of hidden or surprise charges. Commercial and residential users cite a positive experience with the communication and professionalism of the company’s personnel.
All work performed is carried out by technicians described as knowledgeable and dedicated. Licensed and insured status is affirmed in each engagement, aligning with best practices for service firms operating in the climate control industry. The company’s online platform and direct contact channels provide pathways for customers to schedule estimates, access further service details, or raise inquiries about air conditioning care or upgrades.
By launching free estimates, Big Easy Air Conditioning marks a tangible shift toward increased access, allowing anyone considering climate control solutions the opportunity for professional guidance and a detailed proposal prior to engaging services. The policy has been implemented for both new and existing clients and is intended to streamline the first steps toward air conditioning projects for homeowners and businesses alike in the area. For questions customers visit https://www.bigeasyairconditioning.com/contact/.
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For more information about Big Easy Air Conditioning, contact the company here:
Big Easy Air Conditioning Martha Solberg 504-636-8724 info@bigeasyairconditioning.com New Orleans, Louisiana
Findlay, Ohio – October 21, 2025 – PRESSADVANTAGE –
The RED Carpet Connection’s CEO, International neuroscientist, business consultant, and publicist, Dr. Andrea Adams-Miller, acted as one of the Phantoms in cult classic “The Rocky Horror Picture Show,” a live theatre production produced by 3B Productions at the historic Maumee Indoor Theater. The movie celebrated its 50th anniversary, making this live theatre production a fitting tribute. Additionally, this show hails as Dr. Adams-Miller’s seventy-eighth (78) theatrical production.
The Rocky Horror Picture Show has entertained audiences worldwide for half a century with its mix of science fiction, rock music, and comedy. This 3B Productions staging honored the original show’s eccentricity while inviting a new generation to experience the nuance of live theater.
The production was directed by Joe Barton, who led this staging and continued his multi-year history with 3B’s Rocky Horror. Janine Baughman directed the music, and the choreography was by Courtney Austin. Matthew Badyna served as assistant director, supported by Mitchell Antesky, Scott Antesky, and Sarah Kenney on crew, with Tom Miller as spotlight operator, all to enhance the production’s visual precision and rhythm. Additionally, Mark Pike assumed the role of Stage Manager, while Jesse Bernal assumed the role of Producer/Business Manager.
On the 50th anniversary, Director Joe Barton shared that 3B Productions’ decision to bring back the cult fiction was based on popular demand after a 5-year hiatus. Seven (7) original cast members returned to their previous roles or new roles.
The cast included Dylan Haught as Frank-N-Furter, a role originally made famous by Tim Curry in the 1975 film. Jordan Miller portrayed Columbia, first performed by Nell Campbell. Kailyn Jade Wilson took on the role of Magenta, originated by Patricia Quinn, while John Toth brought his background as an educator to Riff Raff, the character created by Richard O’Brien, who also wrote the musical.
Ben Tittl played Brad Majors, first portrayed by Barry Bostwick, and Annabell Welsh performed as Janet Weiss, initially played by Susan Sarandon. Marshall Kupresanin embodied Rocky, the character first brought to life by Peter Hinwood.
Matthew Badyna performed as Eddie, a role popularized by Meat Loaf, while also assisting with direction. Patrick Davis brought heart and humor to Dr. Scott, a role originally portrayed by Jonathan Adams, and Durrell Johnson served as the Narrator, drawing inspiration from Charles Gray’s distinctive delivery in the original production.
The Phantoms ensemble: Dr. Andrea Adams-Miller, Liz Badyna, Ashley Crawford, Caprice Crawford, Jen Crawford, Gus Coutinho, Joyce Coutinho, Emma Glover, Rylie Kregel, Megan Ledyard, Shannon Ruhe, Savanah Stephens, and Shylo Willcutt, contributed to the allure of the mysterious and electric show atmosphere.
Both Dr. Andrea Adams-Miller and Patrick Davis proudly list The Fort Findlay Playhouse in Findlay, Ohio, as their home theater, where they have performed in and supported numerous productions through the years.
“Every actor in this production gave new breath to the movie’s legacy,” said Dr. Andrea Adams-Miller. “The Rocky Horror Picture Show continues to remind us that creativity, self-expression, and community are timeless.”
About Dr. Andrea Adams-Miller:
Dr. Adams-Miller, CEO of TheREDCarpetConnection.com, serves as a Chief Strategic Influence Officer (CSIO) for corporations, entrepreneurs, athletes, celebrities, and influencers. In her professional work as a speaker, publicist, and neuroscientist, she draws from neuroscience, communication, and influence research to guide leaders in strengthening their communication and human connection. While her theater work exists apart from her consulting practice, she integrates performance with influence rooted in authenticity, emotion, and storytelling. All her stage time integrates the study and expression of brain science and communication psychology patterns applied to real-world leadership and media strategy.
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For more information about TheREDCarpetConnection.com, contact the company here:
Dr. Andrea Adams-Miller Dr. Andrea Adams-Miller 4197226931 andreaadamsmiller@theredcarpetconnection.com 8155 Township Road 89
Oceanside, CA – October 22, 2025 – PRESSADVANTAGE –
Moment of Clarity has released a new educational resource, titled “Transcranial Magnetic Stimulation Side Effects,” now available on their website. The article offers an in-depth look at the possible side effects of TMS therapy, a noninvasive, FDA-approved treatment for depression, anxiety, and other mental health conditions. The resource helps patients, families, and communities understand the risks and benefits of TMS, offering clarity at a time when more people are exploring advanced mental health treatments.
The publication explains that TMS therapy utilizes magnetic pulses to stimulate specific areas of the brain associated with mood regulation. While widely regarded as safe and effective, patients often inquire about potential side effects before starting treatment. The article outlines how most side effects are mild, temporary, and well-tolerated, including scalp discomfort or headaches, which usually resolve quickly after sessions. Rare but more serious side effects, such as seizures, are discussed in context with their extremely low risk. By providing transparency, the resource encourages patients to consider TMS as part of a comprehensive treatment plan, rather than avoiding care due to uncertainty.
For individuals in Oceanside, California, seeking individual psychotherapy or couples therapy, this resource situates TMS within the broader spectrum of services that support recovery. Patients often benefit most when TMS is combined with evidence-based talk therapies and holistic approaches. For example, a patient may participate in individual psychotherapy to address underlying thought patterns, engage in couples therapy to improve communication, and involve loved ones in family therapy to strengthen support systems. A psychiatric evaluation often guides these treatment decisions, ensuring TMS is used appropriately alongside other services.
Communities surrounding Oceanside also benefit from access to this type of educational content. In neighborhoods such as El Camino Country Club and Calavera Hills, families frequently seek comprehensive mental health care that blends advanced treatments with counseling and supportive services. The resource reassures patients in these areas that TMS can be safely integrated with outpatient therapy and ongoing evaluations. For patients in Rancho Carlsbad and Carlsbad Village, where people often search for family therapy or psychiatric assessment for mental health, the publication emphasizes the importance of choosing programs that offer both traditional and advanced treatment options, ensuring care is tailored to the unique needs of each patient.
The article also explains that TMS therapy can be particularly effective for patients with treatment-resistant depression. In Oceanside and the surrounding suburbs, patients who have tried multiple medications without success may find TMS to be a promising option. The resource clarifies that TMS is not a replacement for therapy, but rather a complement, designed to improve symptoms sufficiently for patients to engage more fully in psychotherapy and other forms of care. This integration is crucial for families in Carlsbad Village and Calavera Hills, where patients often seek long-term solutions that address both immediate symptoms and deeper causes of mental health challenges.
Moment of Clarity’s publication further emphasizes that transparency about side effects builds trust between patients and providers. By addressing common concerns upfront, the article helps families in Rancho Carlsbad or El Camino Country Club feel more confident in exploring treatment. It highlights that informed patients are more likely to remain engaged in their care, leading to improved outcomes over time.
The resource also highlights the growing recognition that mental health recovery necessitates multiple approaches. For patients in Oceanside, this may include TMS therapy in conjunction with individual psychotherapy, couples therapy, or family therapy to ensure the entire support system is engaged. For people balancing complex needs, psychiatric evaluations provide the foundation for designing personalized care plans. The article emphasizes that advanced treatments, such as TMS, are most effective when they are part of a coordinated, evidence-based program.
By publishing Transcranial Magnetic Stimulation Side Effects, Moment of Clarity reinforces its commitment to patient education and evidence-based care. The resource not only explains the potential risks of TMS but also places them within the broader context of comprehensive mental health services. It provides practical information that patients and their families can use to make informed decisions, thereby reducing uncertainty and stigma surrounding advanced therapies.
For patients and families in Oceanside and nearby neighborhoods such as El Camino and Country Club, searching online for mental health in Oceanside, this new resource offers timely, accessible guidance. By combining clinical expertise with transparent information, Moment of Clarity helps patients and communities better understand TMS therapy, its potential side effects, and its role in supporting recovery.
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For more information about Moment of Clarity Oceanside, contact the company here:
Moment of Clarity Oceanside Marie Mello (949) 288-2392 marie@momentofclarity.com 2215 Mesa Dr, Oceanside, CA 92054
WINTERTHUR, CH – October 10, 2025 – PRESSADVANTAGE –
OMN | Next Gen SEO & KI-Marketing Schweiz announces the expansion of its AI-powered marketing and SEO services specifically designed for Swiss businesses seeking sustainable growth without traditional advertising expenses. The company’s advanced technology platform combines artificial intelligence with semantic SEO techniques to deliver measurable results for companies operating in Switzerland’s multilingual market.
The Swiss digital marketing landscape continues to evolve rapidly as businesses seek more efficient ways to reach customers across German, French, and Italian-speaking regions. OMN’s comprehensive suite of AI-driven services addresses this challenge through automated lead generation, semantic copywriting, and neural data analysis that adapts to local market conditions.
“Swiss businesses require marketing solutions that understand the unique complexities of our multilingual market while delivering concrete results,” said E. Niederer, founder of OMN | Next Gen SEO & KI-Marketing Schweiz. “Our AI technology analyzes market patterns in real-time and automatically adjusts strategies to maximize return on investment for each client, regardless of their target region within Switzerland.”
The company’s approach integrates multiple advanced technologies, including AI-powered lead generation systems that promise a 300 percent increase in qualified contacts, semantic web architecture for improved search rankings, and automated content distribution across platforms. These innovations have positioned OMN at the forefront of Switzerland’s digital marketing transformation.
Recent implementations of OMN’s technology have demonstrated significant improvements in client performance metrics. The company’s semantic SEO methodology achieves top-10 search rankings within 90 days through algorithmic optimization and strategic link building. Additionally, their AI chatbot integration provides 24/7 lead qualification and customer service capabilities without manual intervention.
The expansion of services comes as Swiss businesses increasingly recognize the importance of data-driven marketing strategies. OMN’s Conversion Tracking & Analytics service provides transparent, real-time measurement of marketing activities, allowing companies to refine their efforts based on actual performance data rather than assumptions.
Beyond traditional digital marketing channels, OMN has developed partnerships within the Microsoft ecosystem, offering clients access to MSN, Bing, and Yahoo platforms. This diversification strategy helps Swiss businesses reach audiences that competitors often overlook while maintaining cost efficiency.
The company’s three-tier service structure – Momentum Structure, Cognition Framework, and Omniscale Suite – allows businesses of varying sizes to access AI marketing capabilities previously available only to large enterprises. Each tier incorporates neural data analysis, semantic data integration, and automated content production tailored to specific business needs.
OMN | Next Gen SEO & KI-Marketing Schweiz specializes in AI-powered marketing solutions for Swiss businesses. With over 17 years of experience, the company provides comprehensive digital marketing services, including semantic SEO, automated lead generation, and data analytics, designed specifically for Switzerland’s multilingual market environment. More news about the company can be found here: https://www.pressadvantage.com/story/78283-omn-leads-the-charge-in-next-gen-ai-marketing-seo-revolution-across-switzerland.
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For more information about OMN | Next Gen SEO & KI-Marketing Schweiz, contact the company here:
OMN | Next Gen SEO & KI-Marketing Schweiz E. Niederer hello@omniederer.ch 8400 Winterthur Switzerland
London Borough of Croydon, England – October 23, 2025 – PRESSADVANTAGE –
Smile 4 U Dental Practice – Croydon has announced the availability of consultations for patients considering dentures as part of their restorative dental care. The initiative aims to help individuals who may have lost one or more teeth understand their replacement options in a comfortable and supportive environment.
The practice, which has become a well-known part of the local community, continues to focus on providing patient-centred dental care, offering both NHS and private treatments designed to suit a wide range of needs.
During these newly available denture consultations, patients have the opportunity to discuss how partial or full dentures might work for them, explore modern materials used in denture design, and understand the process involved in achieving a secure, natural-looking fit. The aim is to make sure that each patient receives clear information and guidance before making any treatment decisions. Those wishing to learn more about denture options and how they can restore function and appearance can visit: https://smile4u.co.uk/dentist-croydon/cosmetic-dentistry/dentures/.
The team at Smile 4 U Dental Practice – Croydon recognises that tooth loss can affect more than just appearance. It can also have an impact on speech, eating, and confidence. For this reason, the practice’s approach to dentures focuses on comfort, precision, and aesthetics. During the consultation, a dentist will typically review the patient’s oral health, discuss the most suitable type of denture, and outline what the fitting process involves.
Every stage, from the first impression to the final fit, is explained clearly to ensure patients understand what to expect. Modern dentures are designed to feel lighter, more secure, and more natural than older types, thanks to advances in dental materials and techniques. Patients can also discuss how best to maintain their dentures, with practical advice on cleaning, storage, and long-term care.
Beyond dentures, Smile 4 U Dental Practice – Croydon also offers consultations for a broader range of cosmetic dentistry treatments. These include options for improving the colour, alignment, and overall harmony of the smile. The practice’s cosmetic treatments are intended to blend aesthetics with oral health, ensuring that changes are both natural-looking and sustainable.
Consultations in this area often include a full oral examination, digital imaging where appropriate, and a discussion of achievable outcomes based on the patient’s individual goals. The focus remains on helping patients understand the possibilities without pressure or commitment. For readers who would like to explore the broader range of cosmetic dentistry options available at Smile 4 U Dental Practice, further details can be found at: https://smile4u.co.uk/dentist-croydon/cosmetic-dentistry/.
The practice places equal importance on routine and preventive care, maintaining its reputation as a trusted Croydon dental practice offering a welcoming environment for families and individuals alike. From regular check-ups and hygiene appointments to restorative and aesthetic treatments, the team prioritises personalised care that supports long-term oral health.
These denture consultations align with the practice’s broader goal of helping patients make informed decisions about their dental well-being. They provide a setting where patients can ask questions freely and receive professional advice tailored to their specific needs. The team understands that every case is unique and that replacing missing teeth can feel like a major step, which is why the consultation process is designed to be informative and unhurried.
The team’s ethos is rooted in the belief that restoring a smile should be as much about confidence and comfort as it is about clinical outcomes. Their ongoing investment in training and technology reflects a commitment to maintaining high standards while preserving the human side of dentistry.
For anyone in Croydon seeking to replace missing teeth, enhance their smile, or simply learn more about their oral health options, Smile 4 U Dental Practice is now welcoming new and existing patients for denture consultations. Additional information about the practice, its range of treatments, and how to arrange an appointment can be found at: https://smile4u.co.uk/dentist-croydon/.
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For more information about Smile 4 U – Croydon, contact the company here:
Smile 4 U – Croydon Maryam Shahid +44-20-8640-7586 info@smile4u.co.uk Smile 4 U – Croydon, 357 Addiscombe Road, Croydon CR0 7LG, United Kingdom
As temperatures begin to drop across North Texas, many commercial property owners are turning their attention to the performance and dependability of their heating and cooling systems. Comfort Conditioning, a locally based HVAC service provider, weighs in when it comes to helping business owners understand the importance of prioritizing system maintenance and repairs to ensure optimal efficiency throughout the fall and winter months. The company’s dedicated team provides specialized solutions through its Commercial HVAC Repair program, designed to help commercial operations maintain reliable performance and energy efficiency year-round. With seasonal temperature swings common in the region, consistent system reliability has become a key factor for commercial operations aiming to maintain both energy efficiency and occupant comfort.
According to Kanon Van Guilder, owner of Comfort Conditioning in Krum, Texas, regular maintenance and prompt attention to system issues can make a substantial difference in preventing costly breakdowns during critical periods of operation. The company’s commercial division provides a comprehensive range of professional services tailored to meet the demanding requirements of businesses across multiple industries. These services focus on accurate diagnostics, efficient repairs, and ongoing maintenance strategies that enhance both performance and longevity. By addressing issues such as airflow imbalances, component wear, and energy inefficiencies, businesses can sustain consistent indoor comfort while reducing operational disruptions and unplanned expenses.
Commercial HVAC systems often face heavier usage loads than residential units, requiring precise calibration and maintenance routines to sustain performance. As North Texas experiences fluctuating autumn temperatures that can strain both heating and cooling components, many facility managers are scheduling inspections to prepare for the shift to cooler conditions. A spokesperson for Comfort Conditioning emphasized that proactive maintenance during this transitional period is essential to avoiding disruptions in business operations.
“Commercial HVAC systems are the backbone of a comfortable and productive environment,” said Kanon Van Guilder. “When equipment is neglected or allowed to operate inefficiently, the results can lead to energy waste, premature component failure, and costly downtime.” Van Guilder noted that consistent inspection intervals and data-driven repair decisions are among the most effective strategies for extending system lifespan.
For businesses in sectors such as retail, healthcare, and manufacturing, reliable indoor climate control directly impacts employee performance, equipment safety, and customer satisfaction. Even a short disruption can have measurable consequences, from lost productivity to increased energy consumption when systems must compensate for deferred maintenance. Detailed evaluations that include airflow analysis, filter and coil inspections, and verification of electrical and mechanical integrity are important steps to collectively support efficient operation and energy savings.
Van Guilder explained that many business owners underestimate how early warning signs can escalate. “Unusual noises, inconsistent temperatures, or spikes in utility bills often point to underlying system inefficiencies,” he said. “Addressing these issues promptly allows our clients to avoid full system failures and the resulting loss of comfort or business continuity. Every commercial system requires a customized approach based on usage, square footage, and environmental demands.”
As North Texas businesses prepare for an anticipated increase in heating requirements, energy efficiency remains a critical concern. Aging equipment and deferred maintenance can lead to higher operating costs, even when systems appear to be functioning adequately. Comfort Conditioning’s technicians use diagnostic tools to assess performance metrics such as airflow resistance, refrigerant levels, and heat exchanger condition, identifying opportunities for improved efficiency. By aligning maintenance with operational goals, commercial clients can achieve measurable returns through reduced energy consumption and fewer emergency service calls.
Van Guilder added that many facilities are also exploring system upgrades that integrate modern control technologies and variable-speed components. “Intelligent systems can make real-time adjustments based on building occupancy and temperature fluctuations,” he said. “That level of precision not only improves comfort but also reduces energy waste. Incorporating these technological advancements is becoming more common as part of an overall facility management strategy.”
While system upgrades can offer long-term savings, Comfort Conditioning maintains that maintenance remains the cornerstone of reliability. Routine servicing provides an opportunity to identify and correct inefficiencies before they escalate into expensive repairs. For facilities that operate extended hours or house sensitive equipment, consistent HVAC performance is not merely a matter of comfort—it is essential to business continuity. The company’s technicians are trained to provide service recommendations that balance immediate operational needs with long-term financial efficiency.
Commercial property managers across North Texas have increasingly adopted preventative maintenance agreements as a safeguard against unplanned outages. These agreements allow businesses to schedule routine service checks that align with seasonal changes, ensuring readiness for both heating and cooling demands throughout the year. Van Guilder emphasized that clients who adopt such programs experience fewer emergencies and enjoy more predictable operating budgets. “Preventive maintenance is about control,” he said. “It allows our clients to manage costs, plan ahead, and avoid the unpredictability that comes from reactive repairs.”
In addition to reliability and cost management, environmental considerations are playing a growing role in commercial HVAC decisions. As regulatory standards continue to evolve, energy-efficient systems are becoming a practical and responsible investment for business owners seeking to reduce their carbon footprint. Comfort Conditioning’s commercial repair and maintenance services support compliance with modern energy standards, helping clients achieve both sustainability and operational performance.
Van Guilder concluded by noting that HVAC reliability extends beyond mechanical function—it represents a commitment to operational excellence. “A well-maintained system reflects a business that values safety, efficiency, and comfort,” he said. “As cooler temperatures approach, we encourage every business owner to take a proactive step toward ensuring their HVAC systems are ready to perform when it matters most.”
SAN BERNARDINO, CALIFORNIA / ACCESS Newswire / October 27, 2025 / Dateline Resources Limited (ASX:DTR)(OTCQB:DTREF)(FSE:YE1) (Dateline or the Company) is pleased to provide an update on the drilling activities underway at its 100%-owned Colosseum Gold-REE Project in California, USA.
Three drill rigs are currently operating on site, one diamond rig and two reverse circulation (RC) rigs and until recently, the program was supported by an additional sonic rig that has now completed its tailings stability work and has been demobilised.
The current drilling phase is focused on compact infill, extensional, geotechnical, and tailings stability holes as part of the Bankable Feasibility Study (BFS). The broader program will shortly transition to testing several newly defined, high-priority gold and rare earth targets identified from recent geophysical and geochemical work across the Colosseum system.
Highlights
BFS Drilling: The compact BFS drill program of 32 holes for 4,257 metres (13,968 feet) is 67% complete with an estimated end date of November 7, 2025.
Stockpile Drilling: Approximately 1Mt of historical stockpiles grading ~1 g/t Au will be RC drilled to confirm grade continuity and support inclusion in the mine plan, potentially adding already mined ~30,000oz of gold to the feasibility inventory.
Tailings Stability Drilling: A sonic drilling program over the existing tailings storage facility was completed, confirming the foundation is stable and suitable for additional lifts as part of the planned development.
Exploration Targets: The major phase of the drilling campaign will focus on newly defined gold and rare earth targets, with both programs to be drilled concurrently. Drilling will begin on the high-priority gold breccia pipe targets (Targets 1, 5 and 6) alongside the 2200N REE target, the first of three defined anomalies to be tested.
Dateline’s Managing Director, Stephen Baghdadi, commented:“Having multiple rigs on site has allowed us to accelerate the program so we can focus our efforts sooner on the new gold and rare earth targets. With over 1,400 samples already at the lab, we look forward to reporting the results as they become available and are analysed.
“Our geology team is eager to commence drilling the new gold and REE targets in early November.”
BFS Drill Program Status
Infill and Extensional Program
The Scoping Study outlined 16.6 Mt of ore, with 81% classified as Measured and Indicated and the remaining 19% as Inferred. The current drill program is designed to infill these Inferred areas and support upgrades to Indicated or Measured categories, providing greater confidence in mine scheduling and production planning.
The infill component comprises 32 holes for 4,257 metres (13,968 feet) and is now 67% complete. Samples from the completed holes have been dispatched to ALS Reno for analysis.
Figure 1: RC rig infill drilling the North Pipe at Colosseum
Stockpile Drilling
When Dateline acquired the Colosseum Project in 2021, it inherited an existing ore stockpile left on site following the suspension of operations in 1993. Historical mine records indicate the stockpile contains approximately 1Mt grading 1.0 g/t Au for an estimated 30,000 ounces of gold.
To date, Dateline’s work has focused on expanding the in-situ Mineral Resource, and the stockpile has not yet been drilled or included in the current mine plan. The Company now intends to complete reverse-circulation (RC) drilling to confirm the tonnes and grade of this material, enabling it to be incorporated into the development schedule.
This mined stockpile has the potential to be processed during the commissioning phase of the operation, providing an early source of mill feed, accelerating gold production, and enhancing overall project economics.
Figure 2: Stockpiles to be assessed with RC drilling
Tailings Stability Drilling
Dateline plans to reutilise the existing tailings storage facility (TSF) at Colosseum as part of the proposed mine development. The design involves filter pressing the tailings prior to deposition, allowing the material to be stacked dry on top of the existing facility. This approach enables water recirculation, significantly reducing overall water consumption and supporting construction of additional TSF lifts.
To confirm the suitability of this approach, a program of sonic drilling was completed across the TSF site. The recovered core was reviewed by the Company’s hydrogeological consultants, who have provided their findings to the BFS team. Results confirmed the foundation stability and suitability of the existing TSF for future use as a dry-stack tailings and waste rock facility.
Figure 3: Sonic drill rig on site at the Colosseum TSF
Figure 4: Existing TSF area drilled with sonic drilling
New Target Drilling
The BFS drilling programs were prioritised for completion ahead of the new target testing, as they form part of the critical path for the Colosseum development timeline. With these programs now nearing completion, the focus is shifting to the next phase of drilling-testing the newly defined gold and rare earth element (REE) targets.
Dateline has ranked several high-priority targets for initial assessment, with Gold Targets 1, 5 and 6 and REE Target 2200N to be drilled first as part of the expanded exploration campaign.
Figure 5: New Target Drilling with gold targets 1, 5 and 6 and REE target 2200N shown
This ASX announcement has been authorised for release by the Board of Dateline Resources Limited.
Dateline Resources Limited (ASX: DTR, OTCQB: DTREF, FSE: YE1) is an Australian company focused on mining and exploration in North America. The Company owns 100% of the Colosseum Gold-REE Project in California.
The Colosseum Gold Mine is located in the Walker Lane Trend in East San Bernardino County, California. On 6 June 2024, the Company announced to the ASX that the Colosseum Gold mine has a JORC-2012 compliant Mineral Resource estimate of 27.1Mt @ 1.26g/t Au for 1.1Moz. Of the total Mineral Resource, 455koz @ 1.47/t Au (41%) are classified as Measured, 281koz @1.21g/t Au (26%) as Indicated and 364koz @ 1.10g/t Au (33%) as Inferred.
On 23 May 2025, Dateline announced that updated economics for the Colosseum Gold Project generated an NPV6.5 of US$550 million and an IRR of 61% using a gold price of US$2,900/oz.
The Colosseum is located less than 10km north of the Mountain Pass Rare Earth mine. Planning has commenced on drill testing the REE potential at Colosseum.
Dateline has also acquired the high-grade Argos Strontium Project, also located in San Bernadino County, California. Argos is reportedly the largest strontium deposit in the U.S. with previous celestite production grading 95%+ SrSO4.
Forward-Looking Statements
This announcement may contain “forward-looking statements” concerning Dateline Resources that are subject to risks and uncertainties. Generally, the words “will”, “may”, “should”, “continue”, “believes”, “expects”, “intends”, “anticipates” or similar expressions identify forward-looking statements. These forward-looking statements involve risks and uncertainties that could cause actual results to differ materially from those expressed in the forward-looking statements. Many of these risks and uncertainties relate to factors that are beyond Dateline Resources’ ability to control or estimate precisely, such as future market conditions, changes in regulatory environment and the behaviour of other market participants. Dateline Resources cannot give any assurance that such forward-looking statements will prove to have been correct. The reader is cautioned not to place undue reliance on these forward-looking statements. Dateline Resources assumes no obligation and does not undertake any obligation to update or revise publicly any of the forward-looking statements set out herein, whether as a result of new information, future events or otherwise, except to the extent legally required.
Competent Person Statement
Sample preparation and any exploration information in this announcement is based upon work reviewed by Mr Greg Hall who is a Chartered Professional of the Australasian Institute of Mining and Metallurgy (CP-IMM). Mr Hall has sufficient experience that is relevant to the style of mineralization and type of deposit under consideration and to the activity which he is undertaking to qualify as a Competent Person as defined in the 2012 Edition of the “Australasian Code for Reporting Exploration Results, Mineral Resources and Ore Reserves” (JORC Code). Mr Hall is a Non-Executive Director of Dateline Resources Limited and consents to the inclusion in the report of the matters based on this information in the form and context in which it appears.
Company Confirmations
The Company confirms it is not aware of any new information or data that materially affects the information included in the announcements dated 23 October 2024 with regard to the Colosseum MRE and 23 May 2025 with regard to Colosseum Project Economics. Similarly, the Company confirms that all material assumptions and technical parameters underpinning the estimates and the forecast financial information referred to in those previous announcements continue to apply and have not materially changed.
Icotrokinra demonstrated clinically meaningful outcomes at Week 28 in the Phase 2b ANTHEM-UC study in ulcerative colitis, with 31.7% of patients achieving clinical remission and 38.1% showing endoscopic improvement versus placebo
Updated ANTHEM-UC data support Phase 3 clinical development of icotrokinra in both moderately to severely active ulcerative colitis and Crohn’s disease
In areas of high impact, 72% of patients with scalp psoriasis and 85% with genital psoriasis treated with icotrokinra achieved site-specific clear or almost clear skin at Week 52 in Phase 3 ICONIC-TOTAL study
Further, 67% of patients treated with icotrokinra in the ICONIC-TOTAL study achieved overall rates of clear or almost clear skin by Week 24, which was maintained through Week 52
NEWARK, CALIFORNIA / ACCESS Newswire / October 27, 2025 / Protagonist Therapeutics, Inc. (“Protagonist” or the “Company”) today announced new data from two studies of icotrokinra, a first-in-class investigational targeted oral peptide that precisely blocks the IL-23 receptor, presented at two recent medical conferences.
Week 28 data from the Phase 2b ANTHEM-UC study of icotrokinra will be presented at the 2025 American College of Gastroenterology Annual Scientific Meeting (ACG), demonstrating sustained and clinically meaningful results, with all doses (100 mg, 200 mg and 400 mg) showing higher rates of clinical response a , clinical remission b , endoscopic improvement c and histologic-endoscopic mucosal improvement (HEMI) d at Week 28 compared to placebo. [1] These outcomes build on Week 12 data that was recently presented at United European Gastroenterology (UEG) Week 2025.
Icotrokinra 400 mg once daily
Week 12
Week 28
Placebo (at Week 28)
Clinical response 1
63.5%
66.7%
25.4%
Clinical remission 1
30.2%
31.7%
9.5%
Endoscopic improvement 1
36.5%
38.1%
11.1%
HEMI rates 1
28.6%
33.1%
11.1%
Based on results from the Phase 2b ANTHEM-UC study, Johnson & Johnson has initiated the ICONIC-UC Phase 3 protocol in adults and adolescents with moderately to severely active UC, as well as the ICONIC-CD Phase 2b/3 protocol in adults with moderate to severely active Crohn’s disease.
Additionally, new long-term 52-week data from the Phase 3 ICONIC-TOTAL study e , presented last week at the 2025 Fall Clinical Dermatology Conference, show icotrokinra demonstrated high and durable rates of site-specific psoriasis clearance affecting these high-impact and difficult-to-treat areas of the body. [2]
72% of patients with scalp psoriasis achieved a scalp-specific Investigator’s Global Assessment (ss-IGA) 0/1 score and 57% achieved ss-IGA 0 f
85% of patients with genital psoriasis achieved a Physician’s Global Assessment of Genitalia (sPGA-G) 0/1 and 73% achieved sPGA-G 0 g
In the smaller subset of patients with hand/foot psoriasis, treatment with icotrokinra showed a numerically higher rate of skin clearance at Week 16, which increased through Week 52 with patients achieving a hand and/or foot Physician’s Global Assessment (hf-PGA) h score of 0/1 increasing from 42% to 62%.
Overall response rates among patients treated with once-daily icotrokinra were maintained through Week 52, with 67% of patients treated with icotrokinra achieving clear or almost clear skin (Investigator’s Global Assessment (IGA) i 0/1) and 44% achieving completely clear skin (IGA 0) at Week 52. The overall response rates were also comparable among patients who received icotrokinra for all 52 weeks and those who transitioned from placebo to icotrokinra at Week 16 (67% versus 68% achieved IGA0/1, respectively). Across treatment groups, adverse event and serious adverse event rates were similar through Week 52 compared to those through Week 16, with no new safety signals identified.
“Additional data from Phase 2b ANTHEM-UC and Phase 3 ICONIC-TOTAL studies continue to show a strong durability of response and clinical benefit of icotrokinra treatment in a range of inflammatory and immunological diseases,” said Dinesh V. Patel, Ph.D., President and Chief Executive Officer at Protagonist. “We are very pleased to see that the ICONIC development program now includes both ICONIC-UC, a Phase 3 study in adults with moderately to severely active UC, and ICONIC-CD, a Phase 2b/3 study in adults with moderate to severely active Crohn’s disease. Our goal continues to be delivering well-differentiated oral targeted therapy treatments for patients as we continue to advance our oral peptides-based scientific and innovation leadership in the I&I field.”
Editor’s notes:
Clinical response was defined as a decrease from baseline in the modified Mayo score by greater than or equal to (>=) 30 percent (%) and >=2 points, with either a >=1-point decrease from baseline in the rectal bleeding subscore or a rectal bleeding subscore of 0 or 1.
Clinical remission was defined as a stool frequency subscore of 0 or 1, a rectal bleeding subscore of 0, and an endoscopy subscore of 0 or 1.
Endoscopic improvement was defined as an endoscopy subscore of 0 or 1.
Histologic-endoscopic mucosal improvement (HEMI) was defined as histologic remission (absence of neutrophils from the mucosa in both lamina propria and epithelium, no crypt destruction, and no erosions, ulcerations, or granulation tissue according to the Geboes grading system) and endoscopic improvement (MES of 0 or 1).
ICONIC-TOTAL evaluates the efficacy and safety of icotrokinra compared with placebo in participants with at least moderate scalp, genital, and/or hand/foot PsO with once-daily icotrokinra or placebo, with placebo-to-icotrokinra transition at Week 16.
The ss-IGA is a five-point scale where scalp lesions are assessed in terms of clinical signs of redness, thickness, and scaliness on a severity score ranging from 0 to 4, where 0 indicates absence of disease, 1 is very mild, 2 is mild, 3 is moderate and 4 indicates severe disease.
The sPGA-G is a six-point scale used to evaluate the severity of genital psoriasis at a given time point ranging from 0 to 5, where 0 indicates clear, 1 is minimal, 2 is mild, 3 is moderate, 4 is severe and 5 indicates very severe disease. [3]
The Physician’s Global Assessment of Psoriasis on the Hands and/or Feet (hf-PGA) assesses the severity of hand and foot psoriasis using a 5-point scale to score the plaques on the hands and feet as: clear (0), almost clear (1), mild (2), moderate (3) and severe (4). [4]
The IGA is a five-point scale with a severity score ranging from 0 to 4, where 0 indicates clear, 1 is minimal, 2 is mild, 3 is moderate, and 4 indicates severe disease. [5]
About ANTHEM-UC
ANTHEM-UC ( NCT06049017 ) is a Phase 2b multicenter, randomized, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of icotrokinra (JNJ-77242113, JNJ-2113) in patients with moderately to severely active ulcerative colitis who had an inadequate response or intolerance to conventional therapy (e.g., thiopurines or corticosteroids), prior biologics (TNF antagonists or vedolizumab) and/or ozanimod or approved JAK inhibitors. The study is evaluating three once-daily dosages of icotrokinra taken orally. Participants who complete the Week 28 assessments and have achieved clinical response at Week 28 and who, in the opinion of the investigator, will continue to benefit from treatment with study intervention will continue in the 48-week long term extension (LTE) period and receive the same treatment up to Week 76.
About Ulcerative Colitis Ulcerative colitis (UC) is a chronic disease of the large intestine, also known as the colon, in which the lining of the colon becomes inflamed and develops tiny open sores, or ulcers, that produce pus and mucus. It is the result of the immune system’s overactive response.Symptoms vary but may typically include loose and more urgent bowel movements, rectal bleeding or bloody stool, persistent diarrhea, abdominal pain, loss of appetite, weight loss, and fatigue.
About the ICONIC Clinical Development Program The pivotal Phase 3 ICONIC clinical development program of icotrokinra (JNJ-2113) in adult and pediatric patients 12 years of age and older with moderate-to-severe plaque PsO was initiated with two studies in Q4 2023 – ICONIC-LEAD and ICONIC-TOTAL – pursuant to the license and collaboration agreement between Protagonist Therapeutics, Inc. and Janssen Biotech, Inc., a Johnson & Johnson company.
ICONIC-LEAD ( NCT06095115 ) is a RCT to evaluate the efficacy and safety of icotrokinra compared with placebo in participants with moderate-to-severe plaque PsO, with PASI 90 and IGA score of 0 or 1 with at least a 2-grade improvement as co-primary endpoints.
ICONIC-TOTAL ( NCT06095102 ) is a RCT to evaluate the efficacy and safety of icotrokinra compared with placebo for the treatment of PsO in participants with at least moderate severity affecting special areas (e.g., scalp, genital, and/or hands and feet) with overall IGA score of 0 or 1 with at least a 2-grade improvement as the primary endpoint.
Other Phase 3 studies in the development program include ICONIC-ADVANCE 1 ( NCT06143878 ) and ICONIC-ADVANCE 2 ( NCT06220604 ), which are evaluating the efficacy and safety of icotrokinra compared with both placebo and deucravacitinib in adults with moderate-to-severe plaque PsO. ICONIC-ASCEND will evaluate the efficacy and safety of icotrokinra compared with placebo and ustekinumab in participants with moderate-to-severe plaque psoriasis. ICONIC-PsA 1 ( NCT06878404 ) and ICONIC-PsA 2 ( NCT06807424 ) will evaluate the efficacy and safety of icotrokinra compared to placebo in participants with active psoriatic arthritis.
Johnson & Johnson has also initiated the ICONIC-UC Phase 3 protocol in adults and adolescents with moderately to severely active UC as well as the ICONIC-CD Phase 2b/3 protocol in adults with moderate to severely active Crohn’s disease.
About Plaque Psoriasis Plaque psoriasis (PsO) is a chronic immune-mediated disease resulting in overproduction of skin cells, which causes inflamed, scaly plaques that may be itchy or painful. It is estimated that 8 million Americans and more than 125 million people worldwide live with the disease. Nearly one-quarter of all people with plaque PsO have cases that are considered moderate-to-severe.Plaques typically appear as raised patches with a silvery white buildup of dead skin cells or scales.Plaques may appear red in lighter skin or more of a purple, gray or dark brown color in patients with darker skin tones. Plaques can appear anywhere on the body, although they most often appear on the scalp, knees, elbows, and torso.Living with plaque PsO can be a challenge and impact life beyond a person’s physical health, including emotional health, relationships, and handling the stressors of life. Psoriasis on highly visible areas of the body or sensitive skin, such as the scalp, hands, feet, and genitals, can have an increased negative impact on quality of life.
About Protagonist
Protagonist Therapeutics is a discovery through late-stage development biopharmaceutical company. Two novel peptides derived from Protagonist’s proprietary discovery platform are currently in advanced Phase 3 clinical development, with New Drug Application (NDA) for icotrokinra submitted to the FDA in July and in the NDA submission for rusfertide expected by end of 2025. Icotrokinra (formerly, JNJ-2113), is a first-in-class investigational targeted oral peptide that precisely blocks the Interleukin-23 receptor (“IL-23R”) which is licensed to Janssen Biotech, Inc., a Johnson & Johnson company. Following icotrokinra’s joint discovery by Protagonist and Johnson & Johnson scientists pursuant to the companies’ IL-23R collaboration, Protagonist was primarily responsible for the development of icotrokinra through Phase 1, with Johnson & Johnson assuming responsibility for development in Phase 2 and beyond. Rusfertide, a mimetic of the natural hormone hepcidin, is currently in Phase 3 development for the rare blood disorder polycythemia vera (PV). Rusfertide is being co-developed and will be co-commercialized with Takeda Pharmaceuticals pursuant to a worldwide collaboration and license agreement entered in 2024 under which the Company remains primarily responsible for development through NDA filing. The Company also has a number of preclinical stage drug discovery programs addressing clinically and commercially validated targets, including IL-17 oral peptide antagonist PN-881, obesity triple agonist peptide PN-477, and the oral hepcidin program.
More information on Protagonist, its pipeline drug candidates and clinical studies can be found on the Company’s website at https://www.protagonist-inc.com/ .
Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements regarding the potential benefits of icotrokinra, and expectations regarding the icotrokinra development program. In some cases, you can identify these statements by forward-looking words such as “anticipate,” “believe,” “may,” “will,” “expect,” or the negative or plural of these words or similar expressions. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, our ability to develop and commercialize our product candidates, our ability to earn milestone payments under our collaboration agreements with Johnson & Johnson and Takeda, our ability to use and expand our programs to build a pipeline of product candidates, our ability to obtain and maintain regulatory approval of our product candidates, our ability to operate in a competitive industry and compete successfully against competitors that have greater resources than we do, and our ability to obtain and adequately protect intellectual property rights for our product candidates. Additional information concerning these and other risk factors affecting our business can be found in our periodic filings with the Securities and Exchange Commission, including under the heading “Risk Factors” contained in our most recently filed periodic reports on Form 10-K and Form 10-Q filed with the Securities and Exchange Commission. Forward-looking statements are not guarantees of future performance, and our actual results of operations, financial condition and liquidity, and the development of the industry in which we operate, may differ materially from the forward-looking statements contained in this press release. Any forward-looking statements that we make in this press release speak only as of the date of this press release. We assume no obligation to update our forward-looking statements, whether as a result of new information, future events or otherwise, after the date of this press release.
[1] Jairath V., et al. Efficacy and Safety of Icotrokinra, a Targeted Oral Peptide That Selectively Blocks IL-23 Receptor Activation, In Ulcerative Colitis: Results From Week 28 of ANTHEM-UC, a Phase 2b Dose-ranging Trial. Poster 1066 at ACG Annual Scientific Meeting 2025. October 2025.
[2] Lain, E et al. Durability of Response to the Targeted Oral Peptide Icotrokinra for High-Impact Site Psoriasis: 1-Year ICONIC-TOTAL Findings. Oral presentation (Presentation FC01.1G) at the 2025 Fall Clinical Dermatology Conference. October 2025.
[3] Merola JF, Bleakman AP, Gottlieb AB, et al. The Static Physician’s Global Assessment of Genitalia: a clinical outcome measure for the severity of genital psoriasis. J Drugs Dermatol . 2017;16(8):793-799
[4] Goldblum O, et al. Validation of the physician’s global assessment of psoriasis of the hands and/or feet as a clinical endpoint. J Am Acad Dermatol. 2013:68(4)Supplement1:AB218.
[5] Simpson E, Bissonnette R, Eichenfield LF, et al. The validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD™): The development and reliability testing of a novel clinical outcome measurement instrument for the severity of atopic dermatitis [published online April 25, 2020]. J Am Acad Dermatol. doi: 10.1016/j.jaad.2020.04.104. Accessed April 2025.
