NEW YORK, NY / ACCESS Newswire / December 1, 2025 / Infrastructure is usually easy to identify. Highways, ports, energy grids, data networks, and water systems have defined global progress for decades. But in 2025, the world realized that none of these systems can function smoothly without a capability even more fundamental. Verification.

Verification is becoming the newest category of global infrastructure. It’s not physical, but functional. It makes every other system trustworthy. Without verification, recycling collapses into reporting uncertainty. Commodity markets lose integrity. Supply chains fracture under scrutiny. Compliance becomes theater rather than truth. Verification is the quiet force behind economic coordination, environmental integrity, and regulatory confidence.

SMX (NASDAQ:SMX) built the molecular identity system that turns verification into infrastructure. It gives materials their own digital fingerprint. But to support global adoption across gold, minerals, plastics, textiles, agriculture, and regulated supply chains, the Company needed a financial foundation capable of supporting a multi-region, multi-industry utility.

That foundation is the $111.5 million equity purchase agreement with Target Capital 1, LLC.

Capital Up-Front To Accelerate Mission

The agreement includes a $11.5 million promissory note and access to up to $100 million in capital. SMX chooses when and whether to draw from the facility. There are no forced issuances and no operational restrictions. It’s capital designed for infrastructure level reliability.

That contribution is also expected to allow for no additional shares to be issued under the agreement until at least the first quarter of 2026. That’s based on having money in the bank. Still, at its core, the deal is a valuable strategic asset that will enable SMX to continue advancing its global verification deployments without diluting its capital base in the coming month.

Why is verification now infrastructure? Because no sector can operate without proof. Gold markets demand an authenticated origin. Mineral supply chains require evidence that can survive geopolitical pressure. Plastics circularity programs rely on measurable recovery. Textile and industrial networks depend on authenticated materials. Regulatory bodies need data that can withstand legal and scientific scrutiny. Every system depends on verification.

The agreement also strengthens SMX’s treasury by letting it direct a portion of net proceeds toward digital reserve assets. This reinforces long-term financial resilience in a way that mirrors the decentralized and data-driven nature of the Proof Economy. It can also put a floor on the company’s valuation.

Advancing a Global Utility

Still, what makes the agreement transformative is how it positions SMX to function like a true global utility. Utilities operate across regions and sectors simultaneously. They support entire economies, not individual clients. They exist behind the scenes but determine the reliability of everything in front of them. SMX now holds a capital framework that supports that role.

It can expand gold identity in the Middle East while building plastics passports in Asia. It can scale textile verification in Europe while strengthening mineral authentication in the United States. It can operate across industries without losing focus or momentum.

Verification isn’t a feature anymore. It’s infrastructure. And with its capital structure set and timing provisions clarified, SMX is positioned to anchor the verification systems that modern economies will depend on for decades.

About SMX

As global businesses face new and complex challenges relating to carbon neutrality and meeting new governmental and regional regulations and standards, SMX is able to offer players along the value chain access to its marking, tracking, measuring and digital platform technology to transition more successfully to a low-carbon economy.

Forward-Looking Statements

The information in this press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “will,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements in this press release may include, for example: the ability of SMX to satisfy the conditions under the Equity Purchase Agreement, the Promissory Note and related agreements; successful launch and implementation of SMX’s joint projects with manufacturers and other supply chain participants of steel, rubber and other materials; changes in SMX’s strategy, future operations, financial position, estimated revenues and losses, projected costs, prospects and plans; SMX’s ability to develop and launch new products and services, including its planned Plastic Cycle Token; SMX’s ability to successfully and efficiently integrate future expansion plans and opportunities; SMX’s ability to grow its business in a cost-effective manner; SMX’s product development timeline and estimated research and development costs; the implementation, market acceptance and success of SMX’s business model; developments and projections relating to SMX’s competitors and industry; and SMX’s approach and goals with respect to technology. These forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties. Accordingly, forward-looking statements should not be relied upon as representing views as of any subsequent date, and no obligation is undertaken to update forward-looking statements to reflect events or circumstances after the date they were made, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. As a result of a number of known and unknown risks and uncertainties, actual results or performance may be materially different from those expressed or implied by these forward-looking statements. Some factors that could cause actual results to differ include: the ability to maintain the listing of the Company’s shares on Nasdaq; changes in applicable laws or regulations; the ability to implement business plans, forecasts, and other expectations, and identify and realize additional opportunities; the risk of downturns and the possibility of rapid change in the highly competitive industry in which SMX operates; the risk that SMX and its current and future collaborators are unable to successfully develop and commercialize SMX’s products or services, or experience significant delays in doing so; the risk that the Company may never achieve or sustain profitability; the risk that the Company will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all; the risk that the Company experiences difficulties in managing its growth and expanding operations; the risk that third-party suppliers and manufacturers are not able to fully and timely meet their obligations; the risk that SMX is unable to secure or protect its intellectual property; the possibility that SMX may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties described in SMX’s filings from time to time with the Securities and Exchange Commission.

Media Contact: info@securitymattersltd.com

SOURCE: SMX (Security Matters) Public Limited

View the original press release on ACCESS Newswire

NEW YORK, NY / ACCESS Newswire / December 1, 2025 / Every major shift in global trade is triggered by a gap. A weakness in the system that becomes too large to ignore. For decades, the verification gap was hidden under layers of reporting, audits, certifications, and declarations that looked official but offered limited actual certainty. Whether you were moving gold, producing textiles, refining plastics, exporting minerals, or supplying agricultural inputs, the verification gap sat underneath everything.

In 2025, that gap could no longer be ignored. Supply chains became more complex than the verification systems supporting them. Environmental regulations outpaced reporting tools. Commodity markets demanded authenticity that paperwork couldn’t prove. Nations realized they needed infrastructure capable of confirming the truth behind the materials flowing through their borders.

SMX’s (NASDAQ:SMX) molecular identity platform was already built for this moment. The world simply caught up to it.

Demand Meets SMX’s Technology

This rising demand is what makes SMX’s announced $111.5 million equity purchase agreement so strategically significant. The agreement provides a $11.5 million promissory note and discretionary access to up to $100 million. SMX decides how much to use and when to use it. There are no forced issuances and no restrictions that distort operational priorities.

Based on the initial receipt, that could mean that no shares will be issued under the equity purchase arrangement until at least the first quarter of 2026. This reinforces the Agreement’s strategic purpose. It exists as a financial backbone, ready when needed, while SMX continues executing its 2025 initiatives without immediate capital activity.

The timing is meaningful because the verification gap revealed itself across multiple industries at the same time. Gold markets realized that origin claims without molecular authentication wouldn’t survive scrutiny. Plastics processors realized that recovery claims needed scientific validation. Critical minerals suppliers recognized that compliance regimes required identity that persisted across borders. Textile producers realized that fiber claims needed more than manual certification.

The world didn’t just want proof. It needed proof.

Capital at the Perfect Moment

The equity purchase agreement arrived at the exact moment SMX required capital flexibility to meet simultaneous global demand. It lets SMX scale gold verification, plastic recovery, textile authentication, mineral identity, and industrial frameworks in parallel. The capital structure supports a world that needs multiple verification systems to grow together instead of in sequence.

The agreement also lets SMX allocate part of the net proceeds toward digital reserve assets. This reinforces the Company’s long-term financial resilience and mirrors the decentralized structure of the verification systems SMX is deploying worldwide.

What makes the equity purchase agreement uniquely powerful is how perfectly it aligns with the nature of the verification gap. The gap isn’t industry-specific. It’s systemic. It spans geographies and regulatory environments. SMX’s technology is one of the few solutions capable of addressing it globally. The capital structure enables SMX to respond to the gap wherever it appears.

The verification gap may have caught the world by surprise, but SMX is prepared to close it. With the $111.5 million equity purchase agreement in place and the deployment window defined, SMX holds both the technology and the capital strategy to lead the world into a new era of authenticated, verifiable, evidence-based commerce.

About SMX

As global businesses face new and complex challenges relating to carbon neutrality and meeting new governmental and regional regulations and standards, SMX is able to offer players along the value chain access to its marking, tracking, measuring and digital platform technology to transition more successfully to a low-carbon economy.

Forward-Looking Statements

The information in this press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “will,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements in this press release may include, for example:the ability of SMX to satisfy the conditions under the Equity Purchase Agreement, the Promissory Note and related agreements; successful launch and implementation of SMX’s joint projects with manufacturers and other supply chain participants of steel, rubber and other materials; changes in SMX’s strategy, future operations, financial position, estimated revenues and losses, projected costs, prospects and plans; SMX’s ability to develop and launch new products and services, including its planned Plastic Cycle Token; SMX’s ability to successfully and efficiently integrate future expansion plans and opportunities; SMX’s ability to grow its business in a cost-effective manner; SMX’s product development timeline and estimated research and development costs; the implementation, market acceptance and success of SMX’s business model; developments and projections relating to SMX’s competitors and industry; and SMX’s approach and goals with respect to technology. These forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties. Accordingly, forward-looking statements should not be relied upon as representing views as of any subsequent date, and no obligation is undertaken to update forward-looking statements to reflect events or circumstances after the date they were made, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. As a result of a number of known and unknown risks and uncertainties, actual results or performance may be materially different from those expressed or implied by these forward-looking statements. Some factors that could cause actual results to differ include: the ability to maintain the listing of the Company’s shares on Nasdaq; changes in applicable laws or regulations; the ability to implement business plans, forecasts, and other expectations, and identify and realize additional opportunities; the risk of downturns and the possibility of rapid change in the highly competitive industry in which SMX operates; the risk that SMX and its current and future collaborators are unable to successfully develop and commercialize SMX’s products or services, or experience significant delays in doing so; the risk that the Company may never achieve or sustain profitability; the risk that the Company will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all; the risk that the Company experiences difficulties in managing its growth and expanding operations; the risk that third-party suppliers and manufacturers are not able to fully and timely meet their obligations; the risk that SMX is unable to secure or protect its intellectual property; the possibility that SMX may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties described in SMX’s filings from time to time with the Securities and Exchange Commission.

Media Contact:info@securitymattersltd.com

SOURCE: SMX (Security Matters) Public Limited

View the original press release on ACCESS Newswire

NEW YORK, NY / ACCESS Newswire / December 1, 2025 / Industries once treated materials as interchangeable commodities. Steel was steel. Plastic was plastic. Gold was gold. Cotton was cotton. Identity rarely mattered because the systems relying on those materials weren’t built to authenticate them. But the world changed faster than supply chains did. Today’s markets require something materials never had to provide before. They require intelligence.

Material intelligence means that a material carries identity embedded at the molecular level. It means that proof travels with it from extraction to processing to reuse. It means industrial ecosystems can authenticate origin, verify compliance, and measure recovery with scientific certainty. SMX (NASDAQ:SMX) built the technology that enables that capability. But deploying an era of material intelligence across continents requires financial architecture built for scale, speed, and stability.

This is where the $111.5 million equity purchase agreement, announced Monday, becomes transformational. The agreement provides a $11.5 million promissory note and access to up to $100 million in capital, all at SMX’s discretion. There are no mandatory issuances, and there are no penalties for deliberate pace. It’s financial alignment with the global rollout of molecular identity.

A Controlled Capital Infusion

This initial tranche is expected to keep SMX financially fortified until at least the first quarter of 2026. This creates non-dilutive stability through 2025’s execution cycle and reinforces that the agreement is a strategic resource rather than an immediate lever.

This timing, as well as the deal’s structure, is significant because industries signaled their need for material intelligence all at once. Gold refiners need immutable origin systems capable of reducing uncertainty in high-value markets. Mineral suppliers require molecular identity to meet compliance protocols tied to national security and cross-border trade. Textile manufacturers are preparing for global regulations that demand proof at the fiber level. Plastics circularity programs need authenticated recovery that survives the transformation processes intrinsic to recycling.

SMX operates at the center of all of these shifts.

The equity purchase agreement allows something else. It lets SMX direct a portion of net proceeds toward digital reserve assets. This strengthens the long-term durability of SMX’s treasury structure, can allow its balance sheet to be a value driver, and ensure its strategy aligns with the decentralized, data-driven nature of the Proof Economy. It’s financial infrastructure built for a world where verification itself becomes operational infrastructure.

Advancing A Global Agenda

The agreement enables SMX to scale national systems, industrial programs, and sector-specific frameworks without having to choose between them. Gold identity can expand alongside plastics passports. Textile authentication can grow alongside mineral verification. Agricultural and industrial supply chains can adopt molecular identity in parallel rather than in sequence.

Material intelligence isn’t a trend. It’s the next stage of global industry. Every sector that depends on authenticity, accountability, and circularity is moving toward systems where materials speak for themselves. SMX’s $111.5 million equity purchase agreement gives it the capital foundation to accelerate that shift, and the timing provisions ensure that capital deployment aligns with operational readiness.

This isn’t simply the expansion of a technology platform. It’s the start of a new chapter in how global materials behave, communicate, and integrate into a digital economy built on truth.

About SMX

As global businesses face new and complex challenges relating to carbon neutrality and meeting new governmental and regional regulations and standards, SMX is able to offer players along the value chain access to its marking, tracking, measuring and digital platform technology to transition more successfully to a low-carbon economy.

Forward-Looking Statements

The information in this press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “will,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements in this press release may include, for example:the ability of SMX to satisfy the conditions under the Equity Purchase Agreement, the Promissory Note and related agreements; successful launch and implementation of SMX’s joint projects with manufacturers and other supply chain participants of steel, rubber and other materials; changes in SMX’s strategy, future operations, financial position, estimated revenues and losses, projected costs, prospects and plans; SMX’s ability to develop and launch new products and services, including its planned Plastic Cycle Token; SMX’s ability to successfully and efficiently integrate future expansion plans and opportunities; SMX’s ability to grow its business in a cost-effective manner; SMX’s product development timeline and estimated research and development costs; the implementation, market acceptance and success of SMX’s business model; developments and projections relating to SMX’s competitors and industry; and SMX’s approach and goals with respect to technology. These forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties. Accordingly, forward-looking statements should not be relied upon as representing views as of any subsequent date, and no obligation is undertaken to update forward-looking statements to reflect events or circumstances after the date they were made, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. As a result of a number of known and unknown risks and uncertainties, actual results or performance may be materially different from those expressed or implied by these forward-looking statements. Some factors that could cause actual results to differ include: the ability to maintain the listing of the Company’s shares on Nasdaq; changes in applicable laws or regulations; the ability to implement business plans, forecasts, and other expectations, and identify and realize additional opportunities; the risk of downturns and the possibility of rapid change in the highly competitive industry in which SMX operates; the risk that SMX and its current and future collaborators are unable to successfully develop and commercialize SMX’s products or services, or experience significant delays in doing so; the risk that the Company may never achieve or sustain profitability; the risk that the Company will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all; the risk that the Company experiences difficulties in managing its growth and expanding operations; the risk that third-party suppliers and manufacturers are not able to fully and timely meet their obligations; the risk that SMX is unable to secure or protect its intellectual property; the possibility that SMX may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties described in SMX’s filings from time to time with the Securities and Exchange Commission.

Media Contact:info@securitymattersltd.com

SOURCE: SMX (Security Matters) Public Limited

View the original press release on ACCESS Newswire

NEW YORK, NY / ACCESS Newswire / December 1, 2025 / Trust is the most valuable commodity in the modern economy, yet it’s the hardest to secure. Every sector relies on trust. Gold must confirm origin. Minerals must authenticate purity. Plastics recycling must be proven scientifically. Textile supply chains must verify input claims. Agricultural networks must demonstrate traceability. Aerospace and electronics must confirm authenticity at the part level. No major industry can rely on assumptions anymore. Trust can’t be declared. It has to be demonstrated.

SMX (NASDAQ:SMX) built the molecular identity system that allows trust to be engineered. It gives materials their own voice. And as verification becomes a prerequisite for global trade, capital structures that support verification at an industrial scale become essential.

That’s why the $111.5 million equity purchase agreement with Target Capital 1, LLC is more than financing. It’s the structural platform behind the rise of verification as the operational currency of global supply chains.

Millions Up Front

The agreement provides a $11.5 million promissory note and discretionary access to up to $100 million. SMX chooses when and whether to use this resource. There are no required drawdowns and no penalties for measured execution. It’s capital aligned with precision.

That up-front tranche should also ensure that no shares will be issued under the agreement until at least the first quarter of 2026. That’s based on the expectation that the company will likely not access additional funding under the facility before that period. This keeps the company’s capital structure stable through its current global rollout, reinforcing that the agreement is a strategic mechanism rather than an immediate funding event. And it comes at the perfect moment.

Throughout 2025, industries worldwide pushed toward systems that require measurable authentication. Gold markets needed continuity of identity from mine to vault. Plastics circularity platforms needed proof that doesn’t vanish during processing. Mineral suppliers needed compliance systems that serve both national security mandates and global demand. Textile and industrial suppliers needed frameworks capable of meeting tightening regulations. Every industry began asking for the same thing: evidence.

Stability in a Tough Environment

The equity purchase agreement also supports SMX’s long-term stability by allowing part of the net proceeds to be directed toward digital reserve assets. This reinforces a treasury architecture aligned with the Proof Economy’s decentralized, data-driven nature.

The capital structure also lets SMX serve multiple global systems simultaneously. Gold identity can scale in the Middle East while plastics passports expand in Asia. Textile verification can grow in Europe while mineral authentication advances across North America. The company can maintain momentum in existing markets while entering new ones, all without restricting its operational focus.

Verification is becoming the currency that determines access, integrity, and value across global supply chains. With the $111.5 million equity purchase agreement secured and the timing window clearly defined, SMX has the strategic and financial foundation required to build the systems that make verification universal.

The shift isn’t speculative. It’s already happening. And SMX is positioned at its center.

About SMX

As global businesses face new and complex challenges relating to carbon neutrality and meeting new governmental and regional regulations and standards, SMX is able to offer players along the value chain access to its marking, tracking, measuring and digital platform technology to transition more successfully to a low-carbon economy.

Forward-Looking Statements

The information in this press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements regarding expectations, hopes, beliefs, intentions or strategies regarding the future. In addition, any statements that refer to projections, forecasts or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking statements. The words “anticipate,” “believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,” “forecast,” “intends,” “may,” “will,” “might,” “plan,” “possible,” “potential,” “predict,” “project,” “should,” “would” and similar expressions may identify forward-looking statements, but the absence of these words does not mean that a statement is not forward-looking. Forward-looking statements in this press release may include, for example: the ability of SMX to satisfy the conditions under the Equity Purchase Agreement, the Promissory Note and related agreements; successful launch and implementation of SMX’s joint projects with manufacturers and other supply chain participants of steel, rubber and other materials; changes in SMX’s strategy, future operations, financial position, estimated revenues and losses, projected costs, prospects and plans; SMX’s ability to develop and launch new products and services, including its planned Plastic Cycle Token; SMX’s ability to successfully and efficiently integrate future expansion plans and opportunities; SMX’s ability to grow its business in a cost-effective manner; SMX’s product development timeline and estimated research and development costs; the implementation, market acceptance and success of SMX’s business model; developments and projections relating to SMX’s competitors and industry; and SMX’s approach and goals with respect to technology. These forward-looking statements are based on information available as of the date of this press release, and current expectations, forecasts and assumptions, and involve a number of judgments, risks and uncertainties. Accordingly, forward-looking statements should not be relied upon as representing views as of any subsequent date, and no obligation is undertaken to update forward-looking statements to reflect events or circumstances after the date they were made, whether as a result of new information, future events or otherwise, except as may be required under applicable securities laws. As a result of a number of known and unknown risks and uncertainties, actual results or performance may be materially different from those expressed or implied by these forward-looking statements. Some factors that could cause actual results to differ include: the ability to maintain the listing of the Company’s shares on Nasdaq; changes in applicable laws or regulations; the ability to implement business plans, forecasts, and other expectations, and identify and realize additional opportunities; the risk of downturns and the possibility of rapid change in the highly competitive industry in which SMX operates; the risk that SMX and its current and future collaborators are unable to successfully develop and commercialize SMX’s products or services, or experience significant delays in doing so; the risk that the Company may never achieve or sustain profitability; the risk that the Company will need to raise additional capital to execute its business plan, which may not be available on acceptable terms or at all; the risk that the Company experiences difficulties in managing its growth and expanding operations; the risk that third-party suppliers and manufacturers are not able to fully and timely meet their obligations; the risk that SMX is unable to secure or protect its intellectual property; the possibility that SMX may be adversely affected by other economic, business, and/or competitive factors; and other risks and uncertainties described in SMX’s filings from time to time with the Securities and Exchange Commission.

Media Contact: info@securitymattersltd.com

SOURCE: SMX (Security Matters) Public Limited

View the original press release on ACCESS Newswire

PSA is a validated FDA-recognized clinical endpoint in assessing prostate cancer treatment response; Telomir-1 lowered PSA levels in a dose-related manner.

MIAMI, FLORIDA / ACCESS Newswire / November 25, 2025 / Telomir Pharmaceuticals, Inc. (NASDAQ:TELO) (“Telomir” or the “Company”), a preclinical-stage biotechnology company developing therapies that target epigenetic and metabolic drivers of cancer and age-related disease, today reported new preclinical findings demonstrating that its lead therapeutic candidate, Telomir-1, reduced PSA (prostate-specific antigen) levels in androgen-responsive human prostate cancer cells (LNCaP).

PSA is one of the most widely used and FDA-accepted clinical biomarkers in evaluating prostate cancer treatment activity. PSA is a protein secreted by prostate cancer cells, and elevated PSA levels generally correlate with increased tumor burden and tumor activity. Demonstrating a reduction in PSA in vitro provides additional biological context relevant to Telomir-1’s ongoing preclinical characterization.

Key Findings

In an in vitro study conducted by SmartAssays, LNCaP prostate cancer cells were stimulated with dihydrotestosterone (DHT), a potent androgen that increases PSA production. Under these conditions, Telomir-1 produced a concentration-related reduction in PSA release, paralleling its inhibitory effects on cellular energy metabolism and cell viability.

These in vitro PSA findings are consistent with previously reported Telomir-1 activity in a mouse model implanted with aggressive, non-androgen responsive human prostate cancer cells (PC3 xenografts). In that model, Telomir-1 demonstrated a measurable anti-tumor effect, including approximately 50% reduction in tumor volume when administered as a single agent. In the combination arm of paclitaxel plus Telomir-1, tumor volume was fully reduced, and no mortality occurred. By comparison, paclitaxel alone also resulted in full tumor-volume reduction but was associated with mortality in the study cohort.

The PC3 model represents an androgen-independent tumor type, meaning the cancer cells no longer rely on hormones like testosterone to grow and are generally more aggressive and treatment-resistant. The PSA reductions observed in this new study were generated in androgen-responsive LNCaP cells, which depend on androgen signaling and reflect clinically relevant prostate cancer biology. Together, these datasets indicate that Telomir-1 has shown preclinical activity in both hormone-responsive and hormone-resistant prostate cancer models, based on epigenetic, metabolic, and viability-related measures.

CEO Perspective

“Our mission has always been to advance science that addresses the deeper biological mechanisms driving cancer and aging,” said Erez Aminov, Chief Executive Officer of Telomir. “Patients today still face treatments that are often difficult to tolerate and do not address the underlying drivers of tumor behavior. As we continue developing Telomir-1, our focus remains on exploring these fundamental pathways and generating data that deepen our understanding of the biology at play. Every study adds clarity to the scientific foundation we are building and reinforces why this work matters-for patients, for the field, and for the future of therapies designed to engage the root biology of disease.”

Scientific Perspective

“Despite advances in hormonal therapies, chemotherapy, and targeted agents, prostate cancer continues to present substantial unmet medical needs,” said Dr. Itzchak Angel, Chief Scientific Advisor at Telomir. “Many existing treatments can cause meaningful side effects, including fatigue, metabolic disturbances, cardiovascular strain, and disruptions in sexual function, all of which can significantly affect quality of life and long-term treatment tolerability. There remains a need for additional biological approaches that explore different aspects of tumor biology, and the preclinical findings with Telomir-1 contribute to that ongoing scientific assessment.”

Building on Prior Findings

Across multiple models, Telomir-1 has demonstrated:

• Reduction of PSA levels in androgen-stimulated human prostate cancer cells.

• Reactivation of key tumor-associated pathways in prior studies in prostate cancer, including STAT1, CDKN2A, MASPIN, RASSF1A, and TMS1.

• Activity across epigenetic regulators implicated in tumor progression.

• Anti-cancer activity in a wide range of cancer types, including triple-negative breast cancer, prostate and pancreatic cancers, as well as in leukemia.

• Reduction of oxidative stress and improvements in mitochondrial-related measures in preclinical systems.

• No elongation of telomeres in cancer cells, supporting a favorable preclinical safety profile.

• Approximately 50% reduction in tumor volume and absence of chemotherapy-associated mortality in combination with Paclitaxel in PC3 xenograft work.

Next Steps

Telomir is continuing its preclinical program for Telomir-1 across multiple areas, including oncology, aging biology, autism-related pathways, and other age-associated diseases. In parallel, the Company is advancing its regulatory, IND-enabling activities to support the planned IND submission. These efforts represent essential components of the development pathway, and the Company continues to make meaningful progress as it prepares for future clinical testing.

About Telomir Pharmaceuticals

Telomir Pharmaceuticals (NASDAQ:TELO) is a preclinical biotechnology company developing small-molecule therapeutics that target the root epigenetic mechanisms underlying cancer, aging, and degenerative disease. The Company’s lead candidate, Telomir-1, has demonstrated activity in preclinical studies involving modulation of DNA and histone methylation, restoration of redox balance, and normalization of cellular function.

For more information, please visit www.telomirpharma.com.

Cautionary Note Regarding Forward-Looking Statements

This press release, statements of Telomir’s management or advisors related thereto, and the statements contained in the news story linked in this release contain “forward-looking statements,” which are statements other than historical facts made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These risks and uncertainties include, but are not limited to, the potential use of the data from our studies, our ability to develop and commercialize Telomir-1 for specific indications, and the safety of Telomir-1.

Any forward-looking statements in this press release are based on Telomir’s current expectations, estimates and projections only as of the date of this release. These and other risks concerning Telomir’s programs and operations are described in additional detail in its Annual Report on Form 10-K for the fiscal year ended December 31, 2024, which are on file with the SEC and available at www.sec.gov. Telomir explicitly disclaims any obligation to update any forward-looking statements except to the extent required by law.

Contact Information

Helga Moya
info@telomirpharma.com
(786) 396-6723

SOURCE: Telomir Pharmaceuticals, Inc

View the original press release on ACCESS Newswire

NEW YORK CITY, NY / ACCESS Newswire / November 25, 2025 / REX Shares and Tuttle Capital Management (“T-REX”) today announced the execution of a reverse share split for the following exchange-traded fund (“Fund”):

T-REX 2X Long MSTR Daily Target ETF (Ticker:MSTU)

The total market value of shares outstanding for the Fund will not be affected as a result of this corporate action, except with respect to the redemption of fractional shares, as outlined below.

Please note the following CUSIP change will be effective on December 2, 2025 after market close.

Reverse Split

T-REX will execute a 1-for-10 reverse split of the issued and outstanding shares of T-REX 2X Long MSTR Daily Target ETF.

Fund Name	Ticker	Split Ratio	CUSIP (Old)	CUSIP (New)
T-REX 2X Long MSTR Daily Target ETF	MSTU	1-for-10	26923N462	26923N173

As a result of the reverse share split, shareholders of the Fund will receive one share for every ten shares held as indicated above. Accordingly, the number of the Fund’s issued, and outstanding shares will decrease proportionally, while the total value of each shareholder’s investment will remain unchanged, except for the value of fractional shares redeemed for cash.

Period	Number of Shares Owned	Hypothetical Net Asset Value	Total Market Value
Pre-Reverse Split	10,000	$1.00	$10,000.00
Post-Reverse Split	1,000	$10.00	$10,000.00

The reverse share split will apply to shareholders as of the close of trading on December 2, 2025 (the “Effectuated Date”). Shares of the Fund will begin trading on a split-adjusted basis on December 3, 2025 (the “Effective Date”).

Redemption of Fractional Shares and Tax Consequences of the Reverse Split

As a result of the reverse split, shareholders could potentially hold fractional shares. However, fractional shares cannot trade on the CBOE BZX. Thus, the Fund will redeem for cash a shareholders’ fractional shares at the Fund’s split-adjusted Net Asset Value after the close of the markets on December 2, 2025 (“Effectuated Date”). Such redemption may have tax implications for those shareholders, and shareholders could recognize a gain or loss in connection with the redemption of the shareholders’ fractional shares. Otherwise, the reverse split will not result in a taxable transaction for holders of Fund shares. No transaction fee will be imposed on shareholders for such redemption.

No fractional shares will be issued in connection with the reverse share split. Instead, shareholders will receive cash in lieu of any fractional shares.

“Odd Lot” Unit

Also, as a result of the reverse split, the Fund may have outstanding one aggregation of less than 10,000 shares to make a creation unit, or an “odd lot unit.” Thus, the Fund will provide one authorized participant with a one-time opportunity to redeem the odd lot unit at the split-adjusted NAV or the NAV on such date the authorized participant seeks to redeem the odd lot unit.

The Fund’s transfer agent will notify the Depository Trust Company (“DTC”) of the split and instruct DTC to adjust each shareholders’ investment(s) accordingly. DTC is the registered owner of the Fund’s shares and maintains a record of the Fund’s record owners.

About REX Shares:

REX is an innovative ETF provider that specializes in alternative-strategy ETFs and ETNs. The firm created the MicroSectors™ and co-created the T-REX product lines of leveraged & inverse tools for traders and recently launched the first of a series of option-based income strategies. The firm is rooted in decades of experience building inventive solutions that solve for a range of specific challenges in investor and trader portfolios.

www.rexshares.com

About Tuttle Capital Management (TCM):

TCM is a registered investment adviser and an industry leader in managing thematic ETFs that offer first of their kind of exposures. Please visit www.tuttlecap.com for more information.

About REX Shares and Tuttle Capital Management (“T-REX”)

REX Shares and Tuttle Capital Management are co-developers of the T-REX family of exchange-traded funds, providing tactical investment exposure through leveraged and inverse daily strategies designed to help investors express short-term market views.

Contact Information

David Bogaert
Managing Director, Business Development
dbogaert@ccofva.com
804-267-7416

Chenine Dias
ETF Administration Manager
cdias@ccofva.com
8043677374

SOURCE: Commonwealth Fund Services, Inc.,

View the original press release on ACCESS Newswire